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All cases of the positive group were familial diabetics and there was only one case of dietary treatment, whereas in the negative group, there were only 2 cases of familial diabetics and 3 cases receiving dietary treatment. No statistical differences between the positive and negative groups were observed for the data of exercise performance and hemodynamic parameters in cardiac catheterization at rest. However, the mean ejection fraction in the positive group (62 \u00b1 13%) was significantly lower than in the negative group (77\u00b14%). In both groups, the mean diameter of myocardial cells and the mean percent fibrosis of biopsy specimens showed significant increases compared with the control group. The mean percent fibrosis in the positive group (24.1\u00b18.5%) compared with that in the negative group (16.5\u00b15.9%) showed a tendency to increase. It is suggested that the abnormal perfusion of thallium\u2010201 in the positive group indicates subclinically a pathological change of microcirculation caused by diabetes mellitus.<\/jats:p>","DOI":"10.1002\/clc.4960090804","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T03:27:53Z","timestamp":1233977273000},"page":"375-382","source":"Crossref","is-referenced-by-count":37,"title":["Clinical studies on diabetic myocardial disease using exercise testing with myocardial scintigraphy and endomyocardial biopsy"],"prefix":"10.1002","volume":"9","author":[{"given":"A.","family":"Gend","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nunoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sugihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Namura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Bunko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hisada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.63.1.54"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.45.5.475"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.55.1.79"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90002-8"},{"key":"e_1_2_1_6_1","first-page":"27","article-title":"A study of lesions of the intramural coronary artery branches in diabetes mellitus","volume":"70","author":"Blumenthal HT","year":"1980","journal-title":"Arch Pathol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(81)90600-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.29.7.579"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(80)90379-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198002143020706"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.66.2.342"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(85)90009-X"},{"key":"e_1_2_1_13_1","unstructured":"GendaA TakedaR NakayamaA NunodaS YasudaK TakegoshiT NakanumaY OhotaG:An autopsy case of diabetic cardiomyopathy. 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