{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T21:40:29Z","timestamp":1698010829751},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":8193,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1986,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To compare the effects of ethmozin on sinus node (SN) function in the presence (9 patients) and absence (17 patients) of SN dysfunction, sinus cycle length (SCL), maximal corrected sinus recovery time (CSRT), paced cycle length yielding peak SN suppression, and indirect sinoatrial SA conduction time (SACT) were determined before and after intravenous administration of ethmozin in the dose 2 mg\/kg. The mean \u00b1 SD SCL were significantly shortened in patients with normal SN and were not changed in patients with SN dysfunction after ethmozin administration. The mean maximal CSRT was 252\u00b172 before and 284\u00b186 ms after ethmozin administration in patients with normal SN function (p&lt;0.05). in patients with SN dysfunction (p&lt;0.1) the mean maximal CSRT was found to be 1016\u00b1434 before and 2170\u00b11756 ms after ethmozin administration. The mean SACT was 158\u00b141 before and 174\u00b151 ms after drug administration in patients with normal SN (p&lt;0.05). Four out of nine patients with SN dysfunction developed second degree SA exit block after ethmozin administration, whereas SACT increased significantly in the remaining group of patients (180\u00b135 to 210\u00b132 ms; p&lt;0.05). The PR, PA, AH, and HV intervals significantly lengthened and the valves of QRS and QT were not changed after ethmozin administration in either group. The conclusion is drawn that ethmozin should be administered cautiously to patients with SN dysfunction, particularly to patients with SA exit block, sinus pauses, or secondary pauses (in particular, with bradycardia\u2010tachycardia syndrome).<\/jats:p>","DOI":"10.1002\/clc.4960090911","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T03:28:22Z","timestamp":1233977302000},"page":"443-448","source":"Crossref","is-referenced-by-count":3,"title":["Electrophysiologic effects of ethmozin on sinus node function in patients with and without sinus node dysfunction"],"prefix":"10.1002","volume":"9","author":[{"given":"K. Kh.","family":"Shugushev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. V.","family":"Rosenshtraukh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Smetnev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.1.33"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.54.3.436"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(78)90009-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90411-3"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90412-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(82)90532-4"},{"key":"e_1_2_1_8_1","first-page":"223","volume-title":"Cardiac Arrhythmias","author":"Jordan J","year":"1979"},{"key":"e_1_2_1_9_1","first-page":"182","article-title":"On the pharmacology of ethmozin","volume":"2","author":"Kaverina NV","year":"1972","journal-title":"Farmacologia i Toksicologia USSR"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.59.2.226"},{"key":"e_1_2_1_11_1","first-page":"375","volume-title":"IX World Congress of Cardiology","author":"Mahlers S","year":"1982"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(79)90288-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.61.2.450"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90444-1"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(75)90874-7"},{"key":"e_1_2_1_16_1","first-page":"97","article-title":"Principles and applications electrophysiologic testing of sinus node function","volume":"4","author":"Reiffel JA","year":"1979","journal-title":"Cardiovasc Med"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(77)90007-8"},{"key":"e_1_2_1_18_1","first-page":"291","volume-title":"Effects of ethmozin on the contractile force, transmembrane action potential, and sodium current in frog auricular muscle","author":"Rosenshtraukh LV","year":"1977"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/13.6.354"},{"key":"e_1_2_1_20_1","first-page":"51","article-title":"Electrophysiologic testing in patients with sinus pauses and\/or sinoatrial exit block","volume":"8","author":"Scheinman MM","year":"1978","journal-title":"Eur J Cardiol"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.39.1.13"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(82)90533-6"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960090911","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960090911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T19:02:50Z","timestamp":1697914970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960090911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1986,9]]}},"alternative-id":["10.1002\/clc.4960090911"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960090911","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,9]]}}}