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While platelet function tests were found to be normal with the exception of platelet aggregation rate (PAR), there was a significant rise of factors VIII vWF:Ag (Von Willebrand) and (FPA) fibrinopeptide A. Six cases had high levels of both these factors, suggesting the existence of a particular subset of patients with MVP, with a higher risk of thromboembolic episodes, although only three out of seven patients with previous CVD had either FPA or VIII vWF:Ag levels. The broad spectrum of subjects with MVP probably explains the different results obtained when studying platelet function and coagulation factors. Therefore, larger population studies and prolonged follow\u2010up of cases with either coagulation abnormalities similar to the ones found in the present report and\/or altered platelet function tests are suggested to discover if it is possible to detect patients with a potential for thromboembolism.<\/jats:p>","DOI":"10.1002\/clc.4960091004","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T02:14:59Z","timestamp":1233972899000},"page":"487-492","source":"Crossref","is-referenced-by-count":14,"title":["Platelet function and coagulation studies in patients with mitral valve prolapse"],"prefix":"10.1002","volume":"9","author":[{"given":"A.","family":"Zuppiroli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cecchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ciaccheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Italiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dolara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Longo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Matucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Morfini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Rafanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(77)90208-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500110045008"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1056\/NEJM198001173020303","article-title":"Further evidence relating mitral valve prolapse to cerebral ischemic events","volume":"302","author":"Barnett HJM","year":"1980","journal-title":"N Engl J Med"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03534.x"},{"key":"e_1_2_1_6_1","first-page":"531","article-title":"Circulating platelet aggregates: Absence of correlation with tests of thrombophilia in aged arteriosclerotic patients","volume":"66","author":"Casale G","year":"1981","journal-title":"Haematologica"},{"key":"e_1_2_1_7_1","first-page":"215","article-title":"Beta\u2010thromboglobulina e tempo di rigenerazione piastrinica in soggetti di eta pediatrica portatori di prolasso della valvola mitrale","volume":"13","author":"Cudillo L","year":"1983","journal-title":"G Ital Cardiol"},{"key":"e_1_2_1_8_1","volume-title":"Chromogenic Peptide Substrates Chemistry and Clinical Usage.","author":"Friberger P","year":"1979"},{"key":"e_1_2_1_9_1","volume-title":"Haemostasis and Thrombosis","author":"Gaffney PS","year":"1981"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032717608059125"},{"key":"e_1_2_1_11_1","first-page":"341","article-title":"A study of stroke associated with prolapsed mitral valve","volume":"28","author":"Hanson MR","year":"1978","journal-title":"Neurology"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.11.5.499"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.13.4.429"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.62.2.212"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.41.4.381"},{"key":"e_1_2_1_16_1","volume-title":"Mitral Valve Prolapse.","author":"Jeresaty RM","year":"1979"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.13.4.451"},{"key":"e_1_2_1_18_1","first-page":"47","article-title":"Accident vasculaire cerebral chez des sujets avec un prolapsus de la valve mitrale. 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