{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:11:43Z","timestamp":1776723103938,"version":"3.51.2"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":7706,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to elucidate the trigger factor of the production of torsades de pointes (TdP), electrophysiological study was conducted in 15 patients with atrioventricular (AV) block; 6 with TdP (TdP group) and 9 without TdP (control group). In the TdP group, all had an episode of syncope and frequent ventricular premature beats (VPBs) on routine ECG, while four (44%) had syncope and three (33%) had VPBs in the control group. Aging, QRS width, ventricular cycle length, QT interval, and block site from His bundle electrogram were similar in both groups, however the QT<jats:sub>c<\/jats:sub> interval was significantly (p&lt;0.01) longer in the TdP group than in the control group (580\u00b1112 vs. 459\u00b137, respectively). Furthermore, four patients (67%) in the TdP group showed advanced AV block in which a slow ventricular rate and an irregular rhythm were characteristic, whereas only one control (11%) showed advanced AV block and all other control patients (89%) had complete AV block. These data indicate that patients with advanced atrioventricular block associated with prolonged QT<jats:sub>c<\/jats:sub> interval and frequent ventricular premature beats might induce torsades de pointes.<\/jats:p>","DOI":"10.1002\/clc.4960110111","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T03:26:02Z","timestamp":1233977162000},"page":"9-13","source":"Crossref","is-referenced-by-count":15,"title":["\u201cTorsades de pointes\u201d and atrioventricular block"],"prefix":"10.1002","volume":"11","author":[{"given":"K.","family":"Moroe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Saku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hiroki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"993","article-title":"Torsade de pointes","volume":"173","author":"Agarwal SK","year":"1981","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_1_3_2","first-page":"103","article-title":"Torsades de pointes: Definition and management","volume":"51","author":"Fontaine G","year":"1982","journal-title":"Mod Concepts Cardiovasc Dis"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90224-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.140.9.1223"},{"key":"e_1_2_1_6_2","first-page":"269","article-title":"Torsade de pointes: Polymorphous ventricular tachycardia","volume":"12","author":"Kim HS","year":"1983","journal-title":"Heart Lung"},{"key":"e_1_2_1_7_2","first-page":"263","article-title":"La tachycardie ventriculaire \u00e0 deux foyers oppos\u00e9s variables","volume":"59","author":"Dessertenn F","year":"1966","journal-title":"Arch Mal Coeur"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1986.tb06609.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.63.5.1120"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.129.5.749"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(83)80226-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90081-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.67.1.43"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960110111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960110111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T09:03:00Z","timestamp":1697878980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960110111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1002\/clc.4960110111"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960110111","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}