{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:29:07Z","timestamp":1756992547940},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,8,7]],"date-time":"2009-08-07T00:00:00Z","timestamp":1249603200000},"content-version":"vor","delay-in-days":7433,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Angiotensin converting enzyme (ACE) inhibitors are effective long\u2010term therapy for congestive heart failure, improving symptoms, exercise tolerance, biochemical anomalies, and mortality. Captopril, in doses of up to 150 mg daily is relatively free of serious adverse effects. A test dose of 6.25 mg normally precedes regular therapy in an attempt to avoid first\u2010dose hypotension which may also be prevented by reduction in diuretic dosage and by the avoidance of overdiuresis leading to volume depletion. We report two patients who, despite the above precautions developed symptomatic first\u2010dose hypotension with 6.25 mg, but were subsequently able to recommence captopril therapy by the initial oral administration of doses as low as 1 mg.<\/jats:p>","DOI":"10.1002\/clc.4960120409","type":"journal-article","created":{"date-parts":[[2009,8,8]],"date-time":"2009-08-08T09:24:18Z","timestamp":1249723458000},"page":"225-226","source":"Crossref","is-referenced-by-count":5,"title":["Lower than conventional doses of captopril in the initiation of converting enzyme inhibition in patients with severe congestive heart failure"],"prefix":"10.1002","volume":"12","author":[{"given":"R. A.","family":"Scott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. B.","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,7]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"530","article-title":"Gillen pril in heart failure, A double blind controlled trial.","volume":"52","author":"Cleland JG","year":"1984","journal-title":"J"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706043162301"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)91009-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","unstructured":"LipkinDP FrenneauxM. MaseriA.:Beneficial effect pril in cardiogenic shock.Lancet ii327(1987)","DOI":"10.1016\/S0140-6736(87)90906-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","unstructured":"SharpeDN DouglasJE CoxonRJ:Long BLow d Pril in congestive heart failure: Acute haemodynamic term treatment.Lancetii1154(1980)","DOI":"10.1016\/S0140-6736(80)92593-3"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960120409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960120409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T13:18:14Z","timestamp":1697980694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960120409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,4]]}},"alternative-id":["10.1002\/clc.4960120409"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960120409","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4]]}}}