{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:53:08Z","timestamp":1769921588447,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:00:00Z","timestamp":1233705600000},"content-version":"vor","delay-in-days":7096,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the hemodynamic advantages of rate\u2010responsive (RR) pacing are well established, the symptomatic benefits remain controversial and the effects on the quality of life have not been assessed. Sixteen patients with RR pacemakers and a mean age of 56 (range 22\u201377) years were involved in a double\u2010blind crossover study to assess their exercise capacity (treadmill testing), symptomatology, and quality of life (structured questionnaires). Pacemakers were implanted because of symptomatic heart block or sick sinus syndrome. Ventricular demand pacemakers were randomly programmed into the constant rate (VVI) or RR pacing modes for four\u2010week study periods. All patients exercised longer in the RR mode than in the VVI mode (570\u00b129 vs. 437\u00b117 s, p&lt;0.001). Statistically significant improvements in \u201cshortness of breath\u201d and \u201cenergy during daily activities\u201d as measured by a 10\u2010point scale were reported in the RR pacing mode by the patients and were also observed by their close relatives. Symptoms such as \u201cchest pain\u201d and \u201cpalpitations\u201d were not worsened during RR pacing. Nondisease\u2010specific \u201cquality of life\u201d was studied in 11 patients using the Nottingham Health Profile which showed a trend for an improved quality of life in five of the six dimensions of perceived health, although none of the changes were statistically significant. This study suggests that RR pacing should be recommended in selected patients on symptomatic grounds.<\/jats:p>","DOI":"10.1002\/clc.4960120907","type":"journal-article","created":{"date-parts":[[2009,7,15]],"date-time":"2009-07-15T22:32:01Z","timestamp":1247697121000},"page":"505-512","source":"Crossref","is-referenced-by-count":59,"title":["Symptomatology and quality of life in patients with rate\u2010responsive pacemakers: A double\u2010blind, randomized, crossover study"],"prefix":"10.1002","volume":"12","author":[{"given":"C.\u2010P.","family":"Lau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rushby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Leigh\u2010Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Y. 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