{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:49:06Z","timestamp":1760028546914},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:00:00Z","timestamp":1233705600000},"content-version":"vor","delay-in-days":7066,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The records of 483 patients admitted to the emergency room because of syncope were reviewed. Forty\u2010one patients were found to have drug\u2010related syncope. Thirty\u2010nine experienced syncope related to drugs administered for cardiovascular disease. The most frequently associated diseases were anginal syndrome (22 patients), hypertension (13 patients), and a history of myocardial infarction (6 patients). Thirty\u2010eight patients experienced symptomatic orthostatic hypotension following drug taking (nitrates in 19 patients, beta blockers in 10 patients, nifedipine in 3 patients, prazosin and quinidine in 2 patients each, methyldopa and verapamil in 1 patient each). One patient developed complete heart block as a result of digoxin intoxication. Two patients developed the characteristic picture of anaphylactic reaction (1 with ampicillin, 1 with dipyrone). During one\u2010year follow\u2010up, without the offending medications, no further syncopal episodes were reported by these patients. We conclude that drug\u2010related syncope was more common among our patients with syncope than had been reported previously. It is suggested that drug\u2010related syncope should be taken into consideration in any patient with syncope who is treated by any of the above\u2010mentioned drugs.<\/jats:p>","DOI":"10.1002\/clc.4960121006","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T23:43:01Z","timestamp":1233790981000},"page":"577-580","source":"Crossref","is-referenced-by-count":21,"title":["Drug\u2010related syncope"],"prefix":"10.1002","volume":"12","author":[{"given":"E.","family":"Davidson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Rotenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Agmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198307283090401"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90372-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1001\/jama.1982.03330100023024","article-title":"Patients with syncope admitted to medical intensive care units","volume":"248","author":"Silverstein MC","year":"1982","journal-title":"J Am Med Assoc"},{"key":"e_1_2_1_5_2","first-page":"117","article-title":"Orthostatic hypotension","volume":"56","author":"Thomas JE","year":"1981","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90901-6"},{"key":"e_1_2_1_7_2","first-page":"25","article-title":"Syncope: Evaluation and treatment","volume":"54","author":"Kudencherk PJ","year":"1985","journal-title":"Mod Conc Cardiovasc Dis"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90628-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)91200-7"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706253162606"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.61.3.526"},{"key":"e_1_2_1_12_2","first-page":"49","article-title":"Current status of nitrates in angina pectoris","volume":"56","author":"Thadani U","year":"1987","journal-title":"Mod Conc Cardiovasc Dis"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.54.3.452"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(85)80003-7"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.65.5.886"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1001\/jama.1982.03320370021023","article-title":"A randomized trial of propranolol in patients with acute myocardial infarction. 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