{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:21:31Z","timestamp":1757701291547},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:00:00Z","timestamp":1233705600000},"content-version":"vor","delay-in-days":5847,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1993,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exercise tolerance was assessed in 146 patients with cardiac dysfunction in terms of anaerobic threshold (ATge). Patients were divided into four classes according to the peak oxygen uptake: Class A (72 patients) exceeding 1000 ml\/min; Class B (27 patients) 800\u2010999 ml\/min; Class C (37 patients) 500\u2010799 ml\/min; and Class D (10 patients) below 500 ml\/min. An incidence of the ATge breakpoint was lower in patients of Class C (38%) than in those of either Class B (70%, p &lt; 0.05) or Class A (87%, p &lt; 0.05). The ATge could not be determined in any patients in Class D. The V\u2010slope method improved the ability to determine ATge by 20%. In Classes C and D, ATge detection was precluded considerably by the fact that the initial workloads of exercise test involved oxygen uptake levels already close to or above the ATge. An oscillatory hyperventilation pattern was also significantly related to failure in defining ATge in Class C patients. Of the 51 patients whose ATge was undetermined, 9 had an atrial septal defect In two of these, exercise\u2010induced right\u2010to\u2010left shunting led to progressive arterial hypoxemia, and the consequent hyperventilation masked the appearance of ATge. Thus, ATge is virtually undetectable in patients with severe heart failure largely because of the early onset of anaerobic metabolism or abnormal ventilatory responses to exercise. Accordingly, the clinical application of ATge in the assessment of functional capacity would be limited to patients with mild to moderate heart failure.<\/jats:p>","DOI":"10.1002\/clc.4960160210","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T09:21:15Z","timestamp":1233739275000},"page":"133-137","source":"Crossref","is-referenced-by-count":18,"title":["Limited value of anaerobic threshold for assessing functional capacity in patients with heart failure"],"prefix":"10.1002","volume":"16","author":[{"given":"Kyoko","family":"Miyagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetsugu","family":"Asanoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Ishizaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Kameyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigetake","family":"Sasayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.65.6.1213"},{"key":"e_1_2_1_3_2","unstructured":"LeJemtelTH ManciniD GumbardoD ChadwickB:Pitfalls and limitations of \u201cmaximal\u201d oxygen uptake as an index of cardiovascular functional capacity in patients with chronic heart failure.Heart FailureMay\/June 112\u2013124(1985)"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(64)90012-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.2.360"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90276-3"},{"key":"e_1_2_1_7_2","first-page":"II\u201031","article-title":"Evaluation of severity of heart failure using ventilatory gas analysis","volume":"81","author":"Itoh H","year":"1990","journal-title":"Circulation"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.41.4.544"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1973.35.2.236"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.6.2020"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90326-V"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.5.1558"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)91116-7"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960160210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960160210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T03:45:18Z","timestamp":1698205518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960160210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,2]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,2]]}},"alternative-id":["10.1002\/clc.4960160210"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960160210","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,2]]}}}