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Both facts rely on controversial and partially misleading opinions in the literature. Therefore, a retrospective and prospective study was performed in order to determine the prevalence of LPFB and to correlate its presence to the underlying disease. Retrospective study: Of a cohort of 830 patients referred in 1988 to a cardiologic laboratory for invasive investigation of certain or suspected coronary artery disease (CAD), 163 patients had an old inferior myocardial infarction (IMI). Nine patients (5.5%) showed the typical pattern of LPFB; eight of these had three\u2010vessel disease. The diagnosis of IMI had been made only in one case before entry of the patient into the hospital, since LPFB generally masks IMI. Prospective study: 2502 ECGs were investigated, 1710 from a department of cardiology and 792 from two departments of internal medicine. Six LPFBs were detected (0.24%), all associated with IMI and four of them with three\u2010vessel CAD. It is concluded that LPFB is a rare but clinically important intraventricular conduction disturbance. Its appearance is reliably connected with IMI and generally reflects severe three\u2010vessel CAD, requiring invasive investigation.<\/jats:p>","DOI":"10.1002\/clc.4960160311","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T09:12:40Z","timestamp":1233738760000},"page":"220-226","source":"Crossref","is-referenced-by-count":12,"title":["Isolated left posterior fascicular block: A reliable marker for inferior myocardial infarction and associated severe coronary artery disease"],"prefix":"10.1002","volume":"16","author":[{"given":"Fran\u00e7ois","family":"J. 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