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Numerous trials have shown aspirin to be effective in reducing the risk of myocardial infarction (MI), recurrent transient ischemic attacks, stroke, and vascular death in men at high risk for these events. Primary prevention trials have shown that aspirin reduces the risk of MI in healthy men over 50 years of age but does not reduce the risk of stroke. Two large, multicenter trials have shown that ticlopidine is effective in reducing the risk of fatal and nonfatal stroke in both men and women. Ticlopidine may also be effective in reducing the risk of recurrent stroke in patients who have had a completed thromboembolic stroke.<\/jats:p>","DOI":"10.1002\/clc.4960161004","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T09:40:43Z","timestamp":1233740443000},"page":"703-710","source":"Crossref","is-referenced-by-count":7,"title":["Antiplatelet therapy in the treatment of cerebrovascular disease"],"prefix":"10.1002","volume":"16","author":[{"given":"James R.","family":"Couch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.4.749"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.16.3.416"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.16.3.406"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197807132990201"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908243210804"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92327-1"},{"key":"e_1_2_1_8_2","first-page":"141","volume-title":"Cerebrovascular Survey Report for Joint Council Subcommittee on Cerebrovascular Disease","author":"Millikan CH","year":"1976"},{"key":"e_1_2_1_9_2","first-page":"194","article-title":"Transient cerebral ischemic attacks in a community: Rochester, Minnesota, 1955 through 1969","volume":"48","author":"Whisnant JP","year":"1973","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.210.8.1428"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(60)90045-X"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.11.4_Part_2.152"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/01.STR.13.3.290","article-title":"Survival and recurrence following stroke: The Framingham study","volume":"13","author":"Sacco RL","year":"1982","journal-title":"Stroke"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.3.312"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.7.4.327"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.4.1.20"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6676.789"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.3.541"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.5.577"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198304073081402"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198602203140806"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801283180431"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198907203210301"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6618.313"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.8.3.301"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.14.1.5"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6618.316"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.14.1.15"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1161\/01.STR.22.2.155","article-title":"Stroke recurrence within 2 years after ischemic infarction","volume":"18","author":"Hier DB","year":"1991","journal-title":"Stroke"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.2.325"},{"key":"e_1_2_1_31_2","volume-title":"Data on file"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960161004","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960161004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T15:54:43Z","timestamp":1698249283000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960161004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1993,10]]}},"alternative-id":["10.1002\/clc.4960161004"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960161004","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10]]}}}