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This review deals with pregnancy and congenital heart disease\u2014unoperated and operated. Central to this topic is the intricate interplay between maternal circulatory and respiratory physiology and maternal congenital heart disease, and the effects of this interplay upon the fetus which is exposed to risks that threaten its intrauterine viability and to risks that subsequently express themselves as developmental defects or transmitted congenital malformations of the heart or circulation.<\/jats:p>","DOI":"10.1002\/clc.4960171104","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T06:40:19Z","timestamp":1233729619000},"page":"579-587","source":"Crossref","is-referenced-by-count":40,"title":["Congenital heart disease and pregnancy"],"prefix":"10.1002","volume":"17","author":[{"given":"Joseph K.","family":"Perloff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,4]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"The Bearings of Chronic Disease of the Heart upon Pregnancy, Parturition, and Childbed.","author":"MacDonald A","year":"1878"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06570.x"},{"key":"e_1_2_1_4_2","first-page":"91","volume-title":"Progress in Cardiology","author":"Perloff JK","year":"1992"},{"key":"e_1_2_1_5_2","volume-title":"Heart Disease","author":"Perloff JK","year":"1988"},{"key":"e_1_2_1_6_2","volume-title":"Heart Disease and Pregnancy.","author":"Szekely P","year":"1974"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-3-112-6-445"},{"key":"e_1_2_1_8_2","volume-title":"Burwell and Metcalfe's Heart Disease and Pregnancy","author":"Metcalfe J","year":"1986"},{"key":"e_1_2_1_9_2","volume-title":"Principles of Medical Therapy and Pregnancy","author":"Ueland K","year":"1985"},{"key":"e_1_2_1_10_2","volume-title":"Cardiac Problems in Pregnancy","author":"Wilson A","year":"1982"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70297-7"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(14)80345-3"},{"key":"e_1_2_1_13_2","first-page":"114","volume-title":"Congenital Heart Disease in Adults","author":"Clarke CF","year":"1991"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8469984"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8651(18)30148-6"},{"key":"e_1_2_1_16_2","volume-title":"The Clinical Recognition of Congenital Heart Disease.","author":"Perloff JK","year":"1994"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(86)90692-7"},{"key":"e_1_2_1_18_2","first-page":"111","volume-title":"Congenital Heart Disease in Adults","author":"Child JS","year":"1991"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.55.1.106"},{"key":"e_1_2_1_20_2","first-page":"67","volume-title":"Clinical Evaluation in Percutaneous Balloon Valvuloplasty","author":"Perloff JK","year":"1992"},{"key":"e_1_2_1_21_2","volume-title":"Congenital Heart Disease in Adults","author":"Jarmmakani JM","year":"1991"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(88)90061-5"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-197910000-00001"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.44.5.499"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198210000-00022"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1001\/archinte.1989.00390100059015","article-title":"Heparin therapy during pregnancy. 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