{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:53:19Z","timestamp":1778899999430,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:00:00Z","timestamp":1233705600000},"content-version":"vor","delay-in-days":4783,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to compare the hemodynamic and clinical effects of milrinone, a vasodilating and positive inotropic agent, with those of dobutamine in patients with congestive heart failure (CHF) following acute myocardial infarction (AMI). Thirty\u2010three patients in Killip classification II or III within 12 h to 5 days after AMI were randomized in a multicenter, open\u2010label clinical trial to receive a 24\u2010h infusion of milrinone or dobutamine. Drugs were titrated to achieve at least a 30% increase in cardiac index (CI) from mean baseline or at least a 25% decrease in mean pulmonary capillary wedge pressure (MPCWP) from baseline. Both drugs improved CI, MPCWP, and other hemodynamic parameters. Criteria for decrease in MPCWP were met by 94% (15\/16) of the milrinone\u2010treated patients and 57% (8\/14) of dobutamine\u2010treated patients (p = 0.03). Both groups met the minimum efficacy criterion for CI. Maximal reduction in MPCWP over 0\u20133 h was greater in the milrinone group (\u201053.2%) than in the dobutamine group (\u201031.0%; p \u2264 0.01); reductions were sustained over 24 h. Both drugs improved echocardiographic global ejection fraction and were generally well tolerated. The short\u2010term infusion of milrinone may have a role in the management of CHF following AMI, especially when the aim is the rapid reduction of pulmonary congestion.<\/jats:p>","DOI":"10.1002\/clc.4960190106","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T08:40:02Z","timestamp":1233736802000},"page":"21-30","source":"Crossref","is-referenced-by-count":59,"title":["Comparative efficacy of short\u2010term intravenous infusions of milrinone and dobutamine in acute congestive heart failure following acute myocardial infarction"],"prefix":"10.1002","volume":"19","author":[{"given":"Ronald P.","family":"Karlsberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus A.","family":"DeWood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony 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