{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:51:15Z","timestamp":1780393875059,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":4385,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1997,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The two left ventricular (LV) papillary muscles are small structures but are vital to mitral valve competence. Partial or complete rupture, complicating acute myocardial infarction, causes severe or even catastrophic mitral regurgitation, potentially correctable by surgery. Papillary muscle dysfunction is a controversial topic in that the role of the papillary muscle itself, in causing mitral regurgitation post infarction, has been seriously questioned; it is less confusing if this syndrome is attributed not only to papillary muscle but also to adjacent LV wall ischemia or infarction. Papillary muscle calcification is easily and frequently detected on echocardiography, but its clinical significance remains uncertain. Papillary muscle hypertrophy accompanies LV hypertrophy of varied etiology and may have a significant role in producing dynamic late\u2010systolic intra\u2010LV obstruction in hypertrophic cardiomyopathy and other hyperdynamic hypertrophied LV chambers. All the above abnormalities can be adequately assessed by 2\u2010D echocardiography and the Doppler modalities. In selected cases, transesophageal echocardiography can provide additional valuable data by improving visualization of papillary muscles and mitral apparatus.<\/jats:p>","DOI":"10.1002\/clc.4960200203","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:46:06Z","timestamp":1233708366000},"page":"93-98","source":"Crossref","is-referenced-by-count":62,"title":["The vital role of papillary muscles in mitral and ventricular function: echocardiographic insights"],"prefix":"10.1002","volume":"20","author":[{"given":"Ernest C.","family":"Madu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan A.","family":"D'Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)82310-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90350-A"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.36.1.49"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.64.1.91"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","unstructured":"BurchGE De PasqualeNP PhillipsJH:Clinical manifestations of papillary muscle dysfunction. Arch Intern Med (Chicago)1963;112\u2013117","DOI":"10.1001\/archinte.1963.03860010138015"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-59-4-508"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(96)90193-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90087-4"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.46.1.138"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(71)90051-X"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0022-5223(19)42786-4","article-title":"Experimental papillary muscle infarction","volume":"56","author":"Miller GE","year":"1968","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_1_13_2","first-page":"275","article-title":"Effect of experimental papillary muscle damage on mitral valve closure in intact anesthetized dogs","volume":"45","author":"Tsakiris AG","year":"1970","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.44.2.174"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.5.2167"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90302-4"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90525-2"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(83)80067-8"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-2-149"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(86)80182-6"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.55.5.815"},{"key":"e_1_2_1_22_2","first-page":"I\u2010109","article-title":"The role of echocardiography in the evaluation of mechanical complications of acute myocardial infarction","volume":"84","author":"Buda AJ","year":"1991","journal-title":"Circulation"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)91137-3"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90802-R"},{"key":"e_1_2_1_25_2","first-page":"191","article-title":"Papillary muscle rupture complicating inferior myocardial infarction: Identification with transesophageal echocardiography","volume":"129","author":"Manning WJ","year":"1995","journal-title":"Am Heart J"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80038-5"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/1053-0770(94)90286-0"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(83)80109-X"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0022-5223(19)34007-3","article-title":"Left ventricular outflow tract obstruction and mitral regurgitation caused by papillary muscle abnormalities: A case report","volume":"106","author":"Wada Y","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0022-5223(19)37488-4","article-title":"Obstruction of the left ventricular outflow tract by the mitral valve due to a muscle band","volume":"85","author":"Wright PW","year":"1983","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.36.7.641"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960200203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960200203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T21:51:40Z","timestamp":1698443500000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960200203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["10.1002\/clc.4960200203"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960200203","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}