{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:14:13Z","timestamp":1780416853959,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":4357,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endocarditis is the most devastating complication of brucellosis. The accepted treatment for <jats:italic>Brucella<\/jats:italic> endocarditis (BE) is a combination of valve replacement and antibiotics. Conservative antibiotic treatment alone is not recommended by most authors, as it is considered ineffective, risking fatality. We describe a patient with BE, in whom antibiotic treatment alone resulted in complete recovery. On reviewing the literature, we found 12 additional such cases. We compared this group of 13 patients with data from 49 published cases treated with a combination of surgery and antibiotics, with afavorable outcome. Absence of congestive heart failure or a prosthetic valve, relatively mild extravalvular cardiac involvement, and a somewhat shorter disease history until initiation of treatment were characteristic of the group treated conservatively in comparison with patients who underwent surgery. In selected patients with BE, conservative antibiotic treatment may be a valid alternative to surgery.<\/jats:p>","DOI":"10.1002\/clc.4960200319","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:29:51Z","timestamp":1233707391000},"page":"291-294","source":"Crossref","is-referenced-by-count":38,"title":["Conservative treatment for <i>brucella<\/i> endocarditis"],"prefix":"10.1002","volume":"20","author":[{"given":"Natan","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahuva","family":"Golik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Alon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Zaidenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Dishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Modai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Karpuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzchak","family":"Zyssman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1735","volume-title":"Principles and Practice of Infectious Diseases","author":"Dennis J","year":"1990"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.5.740"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.147.6.1141"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(91)90366-W"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.58.3.279"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0891-5520(20)30510-9","article-title":"Zoonotic endocarditis","volume":"7","author":"Fernandez\u2010Guerrero ML","year":"1993","journal-title":"Infect Dis Clin North Am"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.142.8.1567"},{"key":"e_1_2_1_9_2","first-page":"782","article-title":"Brucella endocarditis: Report of one case and review of the literature","volume":"30","author":"Valliattu J","year":"1989","journal-title":"J Cardiovasc Surg"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S0022-5223(19)35698-3","article-title":"Brucella infective endocarditis: Successful combined medical and surgical therapy","volume":"95","author":"Al\u2010Kasab S","year":"1988","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.6.1532"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1985.tb01647.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.5.907"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.16.3.411"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000174614"},{"key":"e_1_2_1_16_2","first-page":"110","article-title":"Successful treatment of two cases of Brucella endocarditis with rifampicin","volume":"291","author":"Farid Z","year":"1985","journal-title":"Br Med J"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(89)90222-2"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1954.00250040171012"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01979480"},{"key":"e_1_2_1_20_2","first-page":"372","article-title":"Apyrexic Brucella melitensis aortic valve endocarditis","volume":"41","author":"Al Mudallal DS","year":"1989","journal-title":"Trop Geogr Med"},{"key":"e_1_2_1_21_2","first-page":"673","article-title":"Brucellosis and heart disease. 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