{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:30:48Z","timestamp":1788499848812,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":4235,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Low\u2010dose dopamine, a renal vasodilator, has been used empirically to improve renal function or outcome in critically ill patients with oliguria or acute renal failure.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: This study was designed to investigate the efficacy of low\u2010dose dopamine (2 \u03bcg\/kg\/min) as a renal\u2010protective agent during vigorous diuresis for congestive heart failure (CHF) associated with mild or moderate renal insufficiency.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Of 20 study patients (mean age 74.3 \u00b1 15 years) with severe CHF, 10 (Group A) were randomized to a treatment strategy of intravenous bumetanide (1 mg b.i.d.) alone and another 10 (Group B) to low\u2010dose dopamine and a similar diuretic regimen for a duration of 5 days or less if clinical edema remitted.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Group B patients showed a significant improvement in renal function and urinary output: serum blood urea nitrogen 48.9 \u00b1 10.3 to 32.1 \u00b1 14.4 mg\/dl (p&lt;0.05); serum creatinine 1.97 \u00b1 0.24 to 1.49 \u00b1 0.39 mg\/dl (p\u201c0.05); creatinine clearance 35.6 \u00b1 11.6 to 48.8 \u00b1 12.3 ml\/min (p\u201c0.05); and indexed urinary output 0.56\u00b10.16 to 2.02\u00b10.72 ml\/kg\/h (p\u201c0.05). Group A patients showed a significant increase in urinary output but nonsignificant renal functional deterioration.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: The renal\u2010protective effect of low\u2010dose dopamine in the setting of CHF and vigorous diuresis is supported by this study.<\/jats:p>","DOI":"10.1002\/clc.4960200709","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:07:05Z","timestamp":1233706025000},"page":"627-630","source":"Crossref","is-referenced-by-count":46,"title":["The benefit of low\u2010dose dopamine during vigorous diuresis for congestive heart failure associated with renal insufficiency: Does it protect renal 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