{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T10:23:05Z","timestamp":1698574985535},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":4173,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: The mechanisms underlying the excessive ventilatory response to exercise in patients with cardiac failure are still not fully understood.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: This study was undertaken to investigate the mechanisms behind exercise hyperpnea in patients with exercise\u2010induced left ventricular dysfunction.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: In 18 patients, aged 57\u201382 years, all with atherosclerotic lumbar aorta aneurysm and pulmonary artery wedge pressure (PAWP) &gt;25 mmHg during supine exercise, ventilation (V), central hemodynamics, and arterial and venous blood gases were examined during supine rest and exercise, before and during infusion of glyceryl trinitrate (GTN).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Before GTN, exercise PAWP was 32.2 \u00b1 6.1 mmHg and V\/V O<jats:sub>2<\/jats:sub> was 33.8 \u00b1 7.7 1\/1 (130% of predicted). With GTN, exercise PAWP was markedly reduced to 15.3 \u00b1 3.8 mmHg (p &lt; 0.001), whereas V\/V O<jats:sub>2<\/jats:sub> was only marginally reduced to 32.3 \u00b1 3.0 1\/1 (124% of predicted) (p&lt;0.05). Exercise physiologic dead space (V<jats:sub>D<\/jats:sub>\/V<jats:sub>T<\/jats:sub>) declined from 0.31 \u00b1 0.16 to 0.26 \u00b1 0.17 (p&lt;0.05), while PaCO<jats:sub>2<\/jats:sub> was reduced from 5.20 \u00b1 0.31 to 5.10 \u00b1 0.24 kPa (p &lt; 0.05). PvO<jats:sub>2<\/jats:sub> and cardiac output (CO), however, were unchanged, below normal.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: The data show that exercise\u2010induced hyperpnea was not substantially reduced by rapid normalization of PAWP and could not be related to preservation of normal PaCO<jats:sub>2<\/jats:sub> in the presence of high V<jats:sub>D<\/jats:sub>\/V<jats:sub>T<\/jats:sub>. The persistence of exercise hyperpnea and reduced PvO<jats:sub>2<\/jats:sub> after GTN is consistent with augmented ventilatory stimuli from hypoxia\u2010induced metabolic abnormalities in the skeletal muscles, or\/and persistently reduced CO, due to changes in the integrated superior command of ventilation and circulation.<\/jats:p>","DOI":"10.1002\/clc.4960200912","type":"journal-article","created":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T23:52:44Z","timestamp":1233705164000},"page":"773-777","source":"Crossref","is-referenced-by-count":3,"title":["Relationship between exercise hyperpnea, hemodynamics, and blood gases before and during glyceryl trinitrate infusion in patients with exercise\u2010induced elevation of pulmonary artery wedge pressure"],"prefix":"10.1002","volume":"20","author":[{"given":"Lars H.","family":"J\u00f8rgensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Thaulow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald E.","family":"Refsum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"issue":"253","key":"e_1_2_1_2_2","first-page":"111","article-title":"Cardiopulmonary disease and pulmonary ventilation","author":"Erikson H","year":"1960","journal-title":"Acta Chir Scand"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.28.1.1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(76)90019-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-199405000-00008"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(05)80018-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(05)80011-8"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196906000-00002"},{"key":"e_1_2_1_9_2","first-page":"9","article-title":"Ventilatory responses to exercise and to carbon dioxide in mitral stenosis before and after valvulotomy: Causes of tachypnoea","volume":"54","author":"Reed JW","year":"1978","journal-title":"Clin Sci Mol Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.4.1007"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.65.6.1213"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90696-9"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.3.552"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(93)90173-7"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90202-A"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90282-Z"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.2.559"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.3.811"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.3.1144"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.6.2119"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1995.tb01705.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(88)80010-X"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(85)90136-7"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.5.2034"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00523-4"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90900-8"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/14.7.964"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.2.324"},{"issue":"121","key":"e_1_2_1_29_2","first-page":"1","article-title":"Pulmonary gas exchange after exercise of short duration in silicosis","volume":"29","author":"Refsum HE","year":"1972","journal-title":"Scand J Clin Lab Invest"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960170205"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/clc.4960190909","article-title":"Hemodynamic time course of acute and chronic isosorbide dinitrate treatment at rest and during exercise in patients with stable ischemic heart disease","volume":"19","author":"J\u00f8rgensen LH","year":"1996","journal-title":"Clin Cardiol"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1938.tb01244.x"},{"key":"e_1_2_1_33_2","volume-title":"The Lung. Year Book","author":"Comroe JH","year":"1962"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90229-I"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060965"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.72.3.273"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90696-9"},{"key":"e_1_2_1_38_2","first-page":"529","volume-title":"Handbook of Physiology, Section 3, The Respiratory System, Vol. II, Control of Breathing","author":"Daly M de B","year":"1986"},{"key":"e_1_2_1_39_2","first-page":"595","volume-title":"Handbook of Physiology, Section 3, The Respiratory System, Vol. II, Control of Breathing","author":"Wasserman K","year":"1986"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960200912","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960200912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T02:53:20Z","timestamp":1698461600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960200912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1002\/clc.4960200912"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960200912","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}