{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:41:42Z","timestamp":1773297702115,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":3870,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Although nocturnal pulseoximetry is routinely performed in obstructive sleep apnea syndrome (OSAS), pulseoximetry over a 24\u2010h period has not been studied.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: The purpose of the study was to determine whether simultaneous 24\u2010h oxygen desaturation and electrocardiographic (ECG) recording might be used to screen for daytime sleep sequelae in patients with OSAS.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Simultaneous recording of arterial oxygen saturation (SpO2) and ECG was conducted over a 24\u2010h period in 18 male patients with OSAS (mean age 51.3 years) who were diagnosed by standard polysomnography (PSG), and in 15 agematched healthy subjects (mean age 52.7 years) as controls to evaluate circadian variation of these parameters. The measures of heart rate variability (HRV) were calculated from 24\u2010h ambulatory ECGs. Seventeen patients with OSAS showed excessive daytime sleepiness (EDS). We calculated the duration in which SpO<jats:sub>2<\/jats:sub> decreased to &lt;90% (duration of SpO<jats:sub>2<\/jats:sub> &gt; 90%). The number of apnea\/hypopneas per hour (AHI) during sleep was investigated with Apnomonitors (Chest MI, Co., Tokyo) on the same day as the SpO<jats:sub>2<\/jats:sub> recordings.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Controls showed no episodes of oxygen desaturation. in patients with OSAS, driving (33.3% of patients with OSAS) was the most common activity in which SpO<jats:sub>2<\/jats:sub> decreased to &lt;90%, followed by daytime napping (27.8%) and resting after meals (22.2%). The duration of SpO<jats:sub>2<\/jats:sub> &lt; 90% over a 24\u2010h period correlated significantly with the duration levels recorded during sleep (r = 0.99, p &lt; 0.05) and in the afternoon (r = 0.62, p &lt;0.05), and with the AHI (r = 0.55, p&gt;0.05), but not with the duration of SpO<jats:sup>2<\/jats:sup>&gt; 90% in the morning. The number of ventricular premature beats correlated significantly with the duration of SpO<jats:sup>2<\/jats:sup>&gt;90% for a 24\u2010h period, but not with measures of HRV. Ventricular tachycardia was found in two (11.1 %) and ST\u2010T depression in three patients (16.6%) with underlying cardiac diseases.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Our results suggest that daytime sleep attacks accompanied by oxygen desaturation in patients with moderate to severe OSAS may contribute to the occurrence of traffic or cardiovascular accidents. We conclude that 24\u2010h ambulatory recordings of SpO<jats:sup>2<\/jats:sup> and ECG are useful for screening for daytime sleep sequelae associated with the potential risk of this pathology in OSAS during social activities.<\/jats:p>","DOI":"10.1002\/clc.4960210710","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T01:30:23Z","timestamp":1233711023000},"page":"506-510","source":"Crossref","is-referenced-by-count":14,"title":["Twenty\u2010four\u2010hour ambulatory oxygen desaturation and electrocardiographic recording in obstructive sleep apnea syndrome"],"prefix":"10.1002","volume":"21","author":[{"given":"Akiko","family":"Noda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riekol","family":"To","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuonak,","family":"Ashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Yasuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"39","volume-title":"Abnormalities of Respiration during Sleep","author":"Shepard JW","year":"1986"},{"key":"e_1_2_1_3_2","first-page":"365","volume-title":"Sleep and Breathing","author":"Strohl KP","year":"1984"},{"key":"e_1_2_1_4_2","first-page":"400","article-title":"An oxygen desaturation index in the study of sleep apnea syndrome","volume":"16","author":"Okada T","year":"1987","journal-title":"Sleep Res"},{"key":"e_1_2_1_5_2","first-page":"621","volume-title":"Principles and Practice of Sleep Medicine","author":"Lugaresi E","year":"1994"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.94.1.9"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.94.6.1200"},{"key":"e_1_2_1_8_2","first-page":"107","volume-title":"Sleep\/Wake Disorders: Natural History, Epidemiology, and Long\u2010Term Evolution","author":"Guilleminault C","year":"1983"},{"key":"e_1_2_1_9_2","first-page":"81","volume-title":"Obstructive Sleep Apnea Syndrome: Clinical Research and Treatment","author":"Peter JH","year":"1990"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92625-X"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/138.2.337"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90974-3"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.5.7952578"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(83)90013-9"},{"key":"e_1_2_1_15_2","first-page":"197","volume-title":"Sleep Apnea Syndromes","author":"Tilkian AG","year":"1978"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90272-8"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.2.559"},{"key":"e_1_2_1_18_2","first-page":"214","article-title":"A computer analysis of oximetry: Screening of sleep disordered breathing","volume":"52","author":"Yasuma F","year":"1993","journal-title":"Jpn J Chest Dis"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000196231"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.3.618"},{"key":"e_1_2_1_22_2","first-page":"160","volume-title":"Sleep Wakefulness","author":"Okada T","year":"1993"},{"key":"e_1_2_1_23_2","first-page":"311","article-title":"Comparative study between AM and PM sleep in the napping","volume":"15","author":"Yoshiko K","year":"1987","journal-title":"Jpn Soc of EEG & EMG"},{"key":"e_1_2_1_24_2","first-page":"22l","article-title":"The detection and quantification of sleep apnea by trachea! 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