{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:44:14Z","timestamp":1771065854651,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":3372,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1999,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background: Although pulmonary valvular stenosis is not uncommon in adults, there are few reports of percutaneous pulmonary valvuloplasty in adults, despite the possibility of avoiding heart surgery.<\/jats:p><jats:p>Aim: This report describes the experience in adult patients undergoing this procedure and evaluates its effectiveness and tolerance.<\/jats:p><jats:p>Methods: Over an 8\u2010year period (1989\u20131997), pulmonary valvuloplasty was considered in 22 adult patients [8 men, 14 women; mean age 28.0 years \u00b1 standard deviation (SD) 10.3; range 16\u201346 years] with congenital pulmonary valve stenosis. Sixteen patients were asymptomatic with pulmonary systolic murmurs, although 6 patients presented with dyspnea. Before the procedure, the mean transpulmonary valve gradient was 53.2 \u00b1 24.8 mmHg SD, with a mean right ventricular systolic pressure of 74.6 \u00b1 28.4 mmHg SD, and mean pulmonary artery pressure was 21.4 \u00b1 6.4\/10.2 \u00b1 3.9 mmHg.<\/jats:p><jats:p>Results: The procedure was successful in 19 patients (6 men, 13 women) and was well tolerated and free of complications. Following the procedure, the mean transvalvular gradient was 15.5 \u00b1 11.5 mmHg, with a mean right ventricular systolic pressure of 40.5 \u00b1 13.6 mmHg and a mean pulmonary systolic pressure of 24.3 \u00b1 7.4 mmHg. This represented a mean fall in transpulmonary valve gradient of 42.4 \u00b1 22.0 mmHg (paired <jats:italic>t<\/jats:italic>\u2010test, p &lt; 0.0001). After a mean follow\u2010up of 20.1 months (13.4 SD), most patients remained well and asymptomatic, although two patients required repeat valvuloplasty.<\/jats:p><jats:p>Conclusion: Pulmonary valvuloplasty is a well tolerated and effective treatment for pulmonary valve stenosis in adults, with few complications and no need for surgery. This procedure should be considered as the primary treatment of adult patients with pulmonary valve stenosis.<\/jats:p>","DOI":"10.1002\/clc.4960221111","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T03:47:05Z","timestamp":1233719225000},"page":"733-737","source":"Crossref","is-referenced-by-count":10,"title":["Percutaneous balloon valvuloplasty for congenital pulmonary valve stenosis in adults"],"prefix":"10.1002","volume":"22","author":[{"given":"Gregory Y. H.","family":"Lip","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"FRCP","given":"Shyam P.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"FRCP","given":"Joseph","family":"de Giovanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"119","article-title":"Transcatheter treatment of pulmonary outflow tract obstruction: A review","volume":"25","author":"Rao PS","year":"1992","journal-title":"Prog Cardiovasc Dis"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607043350104"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.76.4.363"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198208263070907"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.6.1915"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)90909-5"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90510-R"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(93)90668-Y"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810290203"},{"key":"e_1_2_1_11_2","first-page":"141","article-title":"Echocardiographic evaluation of pulmonary valve stenosis for valvuloplasty in children and adults","volume":"12","author":"Nascimento R","year":"1993","journal-title":"Revista Portuguesa de Cardiologia"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00334-2"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059555"},{"key":"e_1_2_1_14_2","first-page":"63","article-title":"Percutaneous pulmonary valvuloplasty in children and adults: Immediate results","volume":"88","author":"Maatouk F","year":"1995","journal-title":"Arch Maladies Coeur Vaisseaux"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810210204"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.58.2.136"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)91234-9"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)91387-L"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80407-1"},{"issue":"4","key":"e_1_2_1_20_2","first-page":"249","article-title":"Pulmonary valvuloplasty with the balloon catheter. An alternative in the treatment of pulmonary valve stenosis","volume":"42","author":"Fontes VF","year":"1984","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(94)90271-2"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810290203"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90491-X"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80330-7"},{"issue":"3","key":"e_1_2_1_25_2","first-page":"150","article-title":"Pulmonary balloon valvuloplasty for the non\u2010surgical management of valvular pulmonary stenosis","volume":"37","author":"Khalilullah M","year":"1985","journal-title":"Ind Heart J"},{"key":"e_1_2_1_26_2","first-page":"546","article-title":"Percutaneous balloon valvuloplasty for pulmonary valve stenosis using single or double balloon technique","volume":"36","author":"Mashru MR","year":"1988","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_1_27_2","first-page":"112","article-title":"Pulmonary balloon valvuloplasty in the seventh decade of life","volume":"24","author":"Flugelman MY","year":"1988","journal-title":"Israel J Med Sci"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-6-421"},{"key":"e_1_2_1_29_2","first-page":"215","article-title":"Pulmonary valvuloplasty with a balloon catheter in calcified pulmonary valve stenosis","volume":"59","author":"Mora Junior RD","year":"1992","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.5.1456"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.56.535"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960221111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960221111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T20:43:52Z","timestamp":1698525832000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960221111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11,11]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1999,11,11]]}},"alternative-id":["10.1002\/clc.4960221111"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960221111","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11,11]]}}}