{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:40:39Z","timestamp":1762954839449},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":3169,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background:<\/jats:italic>Magnesium depletion and hypomagnesemia are common among furosemide\u2010treated patients with chronic congestive heart failure.<\/jats:p><jats:p><jats:italic>Hypothesis:<\/jats:italic>This investigation evaluated clinical and metabolic effects of oral magnesium supplementation.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic>Ten patients with severe congestive heart failure maintained on high dose furosemide (\u2265 80 mg\/day) received a supplement of oral magnesium citrate 300 mg\/daily for 30 days. Clinical parameters were followed, and peripheral blood mononuclear cell magnesium and zinc content, serum and urine magnesium, potassium, zinc, calcium, phosphorus, and creatinine were assessed.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic>Peripheral blood mononuclear cell magnesium content and serum potassium rose significantly at the end of the study (2.09 \u00b1 1.89 to 3.99 \u00b1 2.26 m\u0308g\/mg cell protein, p&lt; 0.05, and 4.17 \u00b1 0.38 to 4.39 \u00b1 0.27 mEq\/l, p &lt;0.05, respectively), while the other parameters remained unchanged.<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic>In some of these patients, oral magnesium supplementation is effective in achieving substantial increments in intracellular magnesium and serum potassium which, in turn, may have cardioprotective effects.<\/jats:p>","DOI":"10.1002\/clc.4960230611","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T04:39:21Z","timestamp":1233722361000},"page":"433-436","source":"Crossref","is-referenced-by-count":27,"title":["Metabolic and clinical effects of oral magnesium supplementation in furosemide\u2010treated patients with severe congestive heart failure"],"prefix":"10.1002","volume":"23","author":[{"given":"Natan","family":"Cohen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Alon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorit","family":"Almoznino\u2010Sarafian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Weissgarten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Gorelik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Berman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit","family":"Zaidenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahuva","family":"Golik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Modai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)91357-A"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80667-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(94)90633-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.0954-6820.1981.tb02651.x","article-title":"The effect of diuretics on lymphocyte magnesium and potassium","volume":"647","author":"Ryan MP","year":"1981","journal-title":"Acta Med Scand"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90986-M"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90218-X"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90095-I"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1993.tb00663.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1993.tb05883.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.0954-6820.1986.tb18112.x","article-title":"Intracellular electrolytes in cardiac failure","volume":"707","author":"Wester PO","year":"1986","journal-title":"Acta Med Scand"},{"issue":"97","key":"e_1_2_1_12_2","first-page":"77","article-title":"Isolation of mononuclears and granulocytes from human blood","volume":"21","author":"Boyum A","year":"1964","journal-title":"J Clin Lab Inves"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantitive of protein utilizing the principle of protein dye binding","volume":"72","author":"Bradford M","year":"1976","journal-title":"Ann Biochem"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.3.573"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.147.3.465"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6620.455"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5827.620"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1093\/clinchem\/35.7.1559","article-title":"Measurement of magnesium in mononuclear blood cells","volume":"35","author":"Urdal P","year":"1989","journal-title":"Clin Chem"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/clinchem\/36.7.1323","article-title":"Reference value of magnesium and potassium in mononuclear cells and erythrocytes of children","volume":"36","author":"Geven WB","year":"1990","journal-title":"Clin Chem"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1997.10718645"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(88)90193-3"},{"key":"e_1_2_1_22_2","first-page":"366","article-title":"Is oral magnesium replacement antiarrhythmic in patients with congestive heart failure? (abstr)","volume":"21","author":"Gottlieb SS","year":"1993","journal-title":"J Am Coll Cardiol"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960230611","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960230611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T23:53:38Z","timestamp":1710028418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960230611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["10.1002\/clc.4960230611"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960230611","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}