{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:40:08Z","timestamp":1771461608423,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":3169,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background:<\/jats:italic> In hypertensive heart disease, it is uncertain whether the impairment of left ventricular (LV) systolic function might be reverted by antihypertensive treatment.<\/jats:p><jats:p><jats:italic>Hypothesis:<\/jats:italic> This study was undertaken to address the likelihood of recovery of LV dysfunction and to identify factors potentially related.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> Twenty\u2010six patients with primary (n = 16) and renovascular (n = 10) hypertension participated in the study and were classified into Groups A (n = 12) and B (n = 14) according to normalization or persistent left ventricular dysfunction (fractional shortening &lt;0.30) after 36 weeks of follow\u2010up. All patients received standard medical therapy and appropriate procedures for renovascular disease correction. Logistic regression analysis was used to identify variables associated with recovery.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Patients in Group A compared with those in Group B were younger (41\u00b114 vs. 52 \u00b1 10 years; p&lt;0.05), had a greater frequency of renovascular hypertension (8 vs. 2; p&lt;0.05), showed shorter LV end\u2010diastolic (54\u00b15 vs. 61\u00b18 mm; p&lt;0.05) and end\u2010systolic dimensions (41\u00b16 vs. 49\u00b19 mm; p&lt;0.05), and lower mass index (215\u00b164 vs. 261\u00b147 g.m<jats:sup>\u20102<\/jats:sup>; p&lt;0.05) before treatment, whereas fractional shortening (0.24\u00b10.4 vs. 0.20\u00b10.5;p&gt;0.05) and diastolic blood pressure (116\u00b112 vs. 122\u00b119 mmHg; p&gt;0.05) were similar. On follow\u2010up, Group A patients showed lower diastolic blood pressure (89\u00b115 vs. 105\u00b120 mmHg; p&lt;0.05) and mass index (142\u00b134 vs. 222\u00b140 g.m<jats:sup>2<\/jats:sup>; p&lt;0.05). Logistic regression analysis identified systolic dimension and renovascular hypertension as factors associated with fractional shortening normalization.<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> The recovery of LV dysfunction is expected to occur most likely in patients with renovascular hypertension and the shortest systolic dimensions.<\/jats:p>","DOI":"10.1002\/clc.4960230614","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T04:34:56Z","timestamp":1233722096000},"page":"443-448","source":"Crossref","is-referenced-by-count":7,"title":["Normalization of left ventricular dysfunction in systemic hypertension"],"prefix":"10.1002","volume":"23","author":[{"given":"Clovis De Carvalho","family":"Frimm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro Villela","family":"De 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