{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:35:48Z","timestamp":1754195748150},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":3077,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: The rapid utilization of fibrinolytics following Q\u2010wave myocardial infarction has clearly modified the evolution of this disease. However, it is still not known whether the immediate inhibition of platelet aggregation (PA) during the coronary event improves outcomes.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: The present study was designed to test, in patients with known coronary artery disease (chronic stable angina), whether the particular kinetic pattern of lysine acetyl\u2010salicylate (LA) compared with aspirin may affect the time to onset of inhibition of platelet aggregation.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Ten patients suffering from chronic stable angina participated in this study to compare the efficacy and speed of the inhibition of PA with 320 mg of LA versus 320 mg of aspirin. All patients discontinued the use of aspirin and any other anti\u2010inflammatory agents for 15 days prior to the beginning of the study. They were randomly assigned to LA or aspirin. Blood specimens were obtained to measure the PA at admission, and 5,10,20,30, and 60 min after ingestion. Patients continued to take the assigned drug once a day for the following 4 days. On Day 5, a new blood sample was taken. After this, patients underwent a 15\u2010day wash\u2010out period, and then crossed over to the opposite drug. The samples were analyzed immediately using platelet\u2010rich plasma stimulated with adenosine diphosphate (ADP) 2 \u03bcmol\/l, collagen 1 \u03bcg\/ml, epinephrine 20 \u03bcmol\/l, and sodium arachidonate acid 0.75 mm\/l.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: The same level of PA inhibition after 30 and 60 min of aspirin administration can be obtained with LA 5 min following ingestion (sodium arachidonate acid: LA: 16.3 \u00b1 25.9 vs. aspirin 57.6 \u00b1 8.2; p = 0.00014; collagen: LA 18.9 \u00b1 20.1 vs. aspirin 47.2 \u00b1 10.5; p = 0.00092; ADP: LA 27.3 \u00b1 18.4 vs. aspirin 39.7 \u00b1 21.8, p = 0.18; epinephrine: LA 22.0 \u00b1 9.9 vs. aspirin 55.4 \u00b1 10.9, p = 0.00002.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: Platelet aggregation inhibition immediately following LA may have significant clinical implications for the treatment of coronary syndromes.<\/jats:p>","DOI":"10.1002\/clc.4960230912","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T04:18:23Z","timestamp":1233721103000},"page":"697-700","source":"Crossref","is-referenced-by-count":13,"title":["Fast platelet suppression by lysine acetylsalicylate in chronic stable coronary patients. Potential clinical impact over regular aspirin for coronary syndromes"],"prefix":"10.1002","volume":"23","author":[{"given":"Enrique P.","family":"Gurfinkel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Altman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Scazziota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Heguilen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branco","family":"Mautner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"397","article-title":"Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction","volume":"1","author":"Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI)","year":"1986","journal-title":"Lancet"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0140-6736(94)91161-4","article-title":"Indications for fibrinolytic therapy in suspected acute myocardial infarction: Collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1,000 patients","volume":"343","author":"Fibriolytic Therapy Trialists Collaborative Group","year":"1994","journal-title":"Lancet"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199311253292204"},{"key":"e_1_2_1_5_2","first-page":"349","article-title":"Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction","author":"ISIS\u20102 (Second International Study of Infarct Survival) Collaborative Group","year":"1988","journal-title":"Lancet"},{"key":"e_1_2_1_6_2","first-page":"519","article-title":"Multiple doses of regular and enteric\u2010coated aspirin produce equivalent platelet inhibitory effects","volume":"39","author":"Faigel DJ","year":"1986","journal-title":"Curr Ther Res"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb07467.x"},{"key":"e_1_2_1_8_2","first-page":"267","article-title":"Effect de 2 doses d'acetylsalicylate de lysine sur l'agregation plaquettaire, la \u03b2\u2010thromboglobuline et le facteur plaquettaire 4 chez des sujets ag\u00e9s atherosclereux","volume":"43","author":"Roussel 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function","volume":"6","author":"De Caterina R","year":"1985","journal-title":"Eur Heart J"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)91316-V"},{"issue":"6","key":"e_1_2_1_16_2","first-page":"385","article-title":"Pharmacokinetics of salicylic acid following administration of aspirin tablets and three different forms of soluble aspirin in normal subjects","author":"Gatti G","year":"1989","journal-title":"Int J Clin Pharm Res"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198411083111902"}],"container-title":["Clinical 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