{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:55:18Z","timestamp":1775058918862,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":2955,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background: Calcific aortic stenosis may have common etiological factors with atherosclerosis.<\/jats:p><jats:p>Hypothesis: In this retrospective, case\u2010control study, we aimed to determine whether there is an association between hypercholesterolemia and calcific aortic valve stenosis.<\/jats:p><jats:p>Methods: Consecutive patients undergoing single aortic or mitral valve replacement in a regional cardiothoracic surgical center were reviewed and preoperative patient characteristics were recorded: demographics, comorbidity (including coronary artery disease and associated risk factors), serum total cholesterol, lipid\u2010lowering therapy, and serum creatinine.<\/jats:p><jats:p>Results: Serum total cholesterol concentrations were significantly higher in patients with calcific aortic stenosis than in controls (6.2 \u00b1 1.1 vs. 5.3 \u00b1 1.1 mmol\/l;p&lt; 0.001). The significant difference in serum cholesterol concentrations remained following correction for gender and body mass index (p = 0.02) and when patients with coronary artery disease were excluded (6.3 \u00b1 1.1 vs. 5.3 \u00b1 1.4 mmol\/l; p &lt; 0.001). Subgroup analysis demonstrated that the association between elevated serum cholesterol concentrations and calcific aortic stenosis was particularly strong in patients with tricuspid aortic valves (6.4 \u00b1 1.2 vs. 5.3 \u00b1 1.1 mmol\/l; p &lt; 0.001) compared with those with bicuspid valves (5.9 \u00b1 1.1 vs. 5.3 \u00b1 1.1 mmol\/l; p = 0.06).<\/jats:p><jats:p>Conclusions: We conclude that hypercholesterolemia is associated with calcific aortic stenosis and may be implicated in its pathogenesis and progression. We believe that there is now a need for a randomized, controlled trial of cholesterol\u2010lowering therapy in patients with calcific aortic stenosis.<\/jats:p>","DOI":"10.1002\/clc.4960240109","type":"journal-article","created":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T23:37:42Z","timestamp":1233704262000},"page":"52-55","source":"Crossref","is-referenced-by-count":51,"title":["Association between calcific aortic stenosis and hypercholesterolemia: Is there a need for a randomized controlled trial of cholesterol\u2010lowering therapy?"],"prefix":"10.1002","volume":"24","author":[{"given":"Michele C. 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