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In normotensive patients and patients with hypertension treated with long\u2010acting dihydropyridines, medial thickness was thinner than in patients treated with atenolol or in untreated hypertensive patients. Long\u2010term treatment was associated with significant reduction in left ventricular mass. Calcium\u2010channel blockers also improved endothelial\u2010dependent relaxation and reversed the vasoconstrictive response to nitric oxide inhibitors. In diabetic patients. CCBs were effective in preserving kidney function and microalbuminurea. The combination of angiotensin\u2010converting enzyme (ACE) inhibitors and CCBs was more effective than ACE inhibitors alone in preserving kidney function. In animal experiments, CCBs prevented development of coronary atheroschlerosis; however, in humans only limited data are available on their antiatherogenic effect. Some studies suggest that CCBs exert antiplatelets properties and may therefore be beneficial in patients with coronary artery disease.<\/jats:p>","DOI":"10.1002\/clc.4960240202","type":"journal-article","created":{"date-parts":[[2009,8,8]],"date-time":"2009-08-08T09:18:15Z","timestamp":1249723095000},"page":"102-106","source":"Crossref","is-referenced-by-count":3,"title":["End organ protection by calcium\u2010channel 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