{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:49:41Z","timestamp":1784015381729,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,8,7]],"date-time":"2009-08-07T00:00:00Z","timestamp":1249603200000},"content-version":"vor","delay-in-days":3109,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Dobutamine pharmodynamics require approximately 10 min to reach steady state. Despite this, standard dobutamine stress echo typically uses 3\u2010min stages of advancing dobutamine doses because of safety concerns.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: In patients with a high pretest probability of coronary artery disease (CAD), a continuous infusion of high\u2010dose dobutamine is a feasible and safe method for performing a dobutamine stress test.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Forty\u2010seven consecutive patients (mean age 64 \u00b1 11 years) with 3.0 \u00b1 1.4 cardiac risk factors underwent dobutamine stress testing utilizing a single, high\u2010dose (40 mcg\/kg\/min), continuous dobutamine infusion. The 40 mcg\/kg\/min infusion was continued for up to 10 min or until a test end\u2010point had been reached. If a test endpoint was not achieved, atropine (up to 1.0 mg) was added.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Heart rate rose from 71 \u00b1 12 to 137 \u00b1 18 beats\/min at peak (p&lt; 0.0001) with a concomitant change in systolic blood pressure (143 \u00b1 35 vs. 167 \u00b1 38 mmHg; p = 0.001) but no change in diastolic blood pressure (74 \u00b1 19 vs. 75 \u00b1 18 mmHg; p = NS). Target heart rate was achieved in 20 of 47 (43%) patients with accelerated dobutamine alone and in 34 of 47 (72%) with the addition of atropine. An average of 11.6 \u00b1 3.7 min was required to obtain target heart rate. Subjective sensations from the dobutamine occurred in 49% of patients (palpitations 21%, nausea 6%, chest pain 6%, headache 6%, dizziness 13%), mild arrhythmia in 48% of patients (ventricular premature beats 38%, supraventricular tachycardia 10%), and one patient had nonsustained ventricular tachycardia.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: A single, high\u2010dose (40 mcg\/kg\/min) dobutamine\u2010atropine protocol provides an efficient means of performing dobutamine stress echocardiography with a similar symptom profile as conventional dobutamine infusion protocols in patients with a high pretest probability of CAD. Randomized, controlled studies will be necessary to assess the sensitivity and specificity of this accelerated dobutamine echo protocol.<\/jats:p>","DOI":"10.1002\/clc.4960240208","type":"journal-article","created":{"date-parts":[[2009,8,8]],"date-time":"2009-08-08T09:18:45Z","timestamp":1249723125000},"page":"141-145","source":"Crossref","is-referenced-by-count":19,"title":["Accelerated dobutamine stress testing: Safety and feasibility in patients with known or suspected coronary artery disease"],"prefix":"10.1002","volume":"24","author":[{"given":"David","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qudsia","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Fernicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,8,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90675-0"},{"key":"e_1_2_1_3_2","first-page":"1451","volume-title":"Physicians' Desk Reference","author":"Arky R.","year":"1998"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00039-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80254-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)91387-J"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00195-7"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00450-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00558-X"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.2.405"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00289-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.1.15"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960240208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960240208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T10:09:52Z","timestamp":1696673392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960240208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["10.1002\/clc.4960240208"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960240208","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}