{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T22:45:01Z","timestamp":1759099501849},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":2774,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Backgrvund:<\/jats:italic> The putative theory is that the clinical syndrome of unstable angina is caused by rupture of the atherosclerotic plaque with superimposed thrombus formation. It is characterized by angiographically complex coronary lesions in the majority of patients.<\/jats:p><jats:p><jats:italic>Hypothesis:<\/jats:italic> This study aimed at assessing the correlation between C\u2010reactive protein (CRP) and the complexity of culprit coronary lesions in unstable angina.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> We identified culprit lesion complexity in 96 patients with unstable angina and normal creatine kinase (CK) and CK\u2010MB mass. Serum concentrations of CRP (N &lt; 5.0 mg\/1) and cardiac troponin T (cTnT; N &lt; 0.1 ng\/ml) were measured on admission.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> There was a trend toward a higher grade of anatomical complexity of the culprit lesion in patients with elevated CRP (p=0.007) and cTnT levels (p=0.027). Patients who had intermediate\u2010 or high\u2010grade lesion severity had a higher level of CRP (8.5 \u00b15.7 mg\/1) and cTnT (0.118 \u00b1 0.205 ng\/ml) on admission than those who had normal or low\u2010grade lesions (5.7 \u00b1 4.0 mg\/1,0.017 \u00b10.021 ng\/ml, respectively); Mann\u2010Whitney U, p=0.002 and p &lt; 0.001, respectively. Furthermore, the likelihood of having intermediate\u2010 or high\u2010grade complexity of the culprit lesion was higher when CRP levels were elevated in all patients (p = 0.007, odds ratio [OR] = 4.286; 95% confidence interval [CI] 1.492\u201312.310) and in those with normal cTnT levels (p = 0.025, OR = 3.876; 95% CI 1.185\u201312.678). Also, higher CRP levels strongly correlated with the need for revascularization interventions (p &lt; 0.0005).<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> Elevated CRP level on admission is a marker for anatomic complexity of culprit lesions and need for revascularization interventions in unstable angina.<\/jats:p>","DOI":"10.1002\/clc.4960240718","type":"journal-article","created":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T23:07:45Z","timestamp":1233702465000},"page":"506-510","source":"Crossref","is-referenced-by-count":18,"title":["C\u2010Reactive protein is a marker for a complex culprit lesion anatomy in unstable angina"],"prefix":"10.1002","volume":"24","author":[{"given":"George V.","family":"Moukarbel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Samir A.","family":"Arnaout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir E.","family":"Alam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80384-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.1.17"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.775"},{"key":"e_1_2_1_5_2","first-page":"159","article-title":"Correlation of morphological variables in the coronary atherosclerotic plaque with clinical patterns of ischemic heart disease","volume":"2","author":"Baroldi G","year":"1988","journal-title":"Am J Cardiovasc Pathol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(87)90198-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.71.4.709"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.36"},{"key":"e_1_2_1_9_2","first-page":"105","article-title":"Inflammation of the coronary arteries in patients with unstable angina","volume":"16","author":"Wallash E","year":"1986","journal-title":"Tex Heart Inst J"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(81)90005-X"},{"key":"e_1_2_1_11_2","first-page":"1527","volume-title":"Oxford Textbook of Medicine","author":"Pepys MB","year":"1995"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704033361401"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90079-G"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408183310701"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.10.2373"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07591-5"},{"key":"e_1_2_1_17_2","article-title":"C\u2010reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: A TIMI 11A substudy","author":"Morrow DA","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00018-8"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.2.410"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90431-7"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.11.2844"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00207-7"},{"key":"e_1_2_1_23_2","first-page":"1","article-title":"Serum troponin T levels predict coronary angiographic findings in patients with unstable angina","volume":"92","author":"Jurlander B","year":"1995","journal-title":"Circulation"},{"key":"e_1_2_1_24_2","first-page":"116","article-title":"Incidence and risk of coronary revascularization in unstable angina according to the troponinTstatus(abstr)","volume":"19","author":"Heeschen C","year":"1998","journal-title":"Eur Heart J"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905273402103"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960240718","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960240718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T19:07:06Z","timestamp":1700420826000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960240718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["10.1002\/clc.4960240718"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960240718","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7]]}}}