{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T17:52:57Z","timestamp":1721843577822},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":2743,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Risk stratification of patients with unstable angina or non\u2010Q\u2010wave myocardial infarction (MI) is an unresolved clinical problem. The prognostic value of T\u2010wave normalization (TWN) during exercise has not been studied in this group of patients.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: Event\u2010free survival in clinically stable patients after an acute coronary event without ST\u2010segment elevation can be predicted by the presence of exercise\u2010induced TWN.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Sixty\u2010five patients (43 men and 22 women, mean age 62 \u00b1 10 years) entered the study. The diagnosis of unstable angina and non\u2010Q\u2010wave MI was made in 40 and 25 patients, respectively. A treadmill exercise test was performed in all patients after clinical stabilization. The patients were divided into three groups: those with negative baseline T waves and exercise\u2010induced TWN (Group 1); those with negative baseline T waves, but without TWN (Group 2); and those with positive baseline T waves (Group 3). The patients were followed up for 6 months.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: During follow\u2010up, serious cardiovascular complications occurred in 15 (23%) patients. These included exacerbation of ischemic heart disease (14 patients) and acute MI (1 patient). Event\u2010free survival was greater in patients in Group 1 (95%) than in those in Group 2 (68%, p &lt; 0.034) or Group 3 (71%, NS). Among all patients studied, exercise\u2010induced TWN was predictive of event\u2010free survival with a sensitivity of 38% and a specificity of 93%.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: In clinically stable patients after an acute coronary event without ST\u2010segment elevation, exercise\u2010induced TWN is a specific but not sensitive predictor of event\u2010free survival after 6 months.<\/jats:p>","DOI":"10.1002\/clc.4960240808","type":"journal-article","created":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T23:05:31Z","timestamp":1233702331000},"page":"564-569","source":"Crossref","is-referenced-by-count":3,"title":["Event\u2010free survival in patients after an acute coronary event with exercise\u2010induced normalization of the 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