{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:47:27Z","timestamp":1769914047787,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":2682,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Paroxysmal atrial fibrillation (PAF), a common arrhythmia, is caused by the fractionated and nonhomo\u2010geneous propagation of sinus impulse.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: This study was undertaken to examine the effect of left atrial (LA) dimension and function on P\u2010wave dispersion (\u0394P) in unselected patients with PAF and healthy controls.<\/jats:p><jats:p><jats:italic>Method<\/jats:italic>: In this study, 62 consecutive patients with PAF (32 men, 30 women, mean age 55 \u00b1 11 years) and 62 age\u2010 and gender\u2010matched healthy controls (33 men, 29 women, mean age 52 \u00b1 13 years) were studied to compare the effect of LA size, volume, and function on \u0394P (difference between maximum and minimum P\u2010wave duration on 12\u2010lead electrocardiogram).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: P\u2010wave dispersion in patients with PAF and normal LA diastolic diameter (LAD) was longer than that in controls with normal LA size (53 \u00b1 8 vs. 34 \u00b1 8 ms, p &lt; 0.001). P\u2010wave dispersion increased in patients with PAF (62 \u00b1 12 vs. 53 \u00b1 8 ms, p = 0.003) and controls (40 \u00b1 7 vs. 34 \u00b1 8 ms, p = 0.005) with increased LAD. Presence or absence of PAF did not interact with LAD for their effect on \u0394P (2 \u00d7 2 analysis of variance test p = 0.20). In the PAF group, \u0394P correlated with LAD (r = 0.43, p = 0.002), LA diastolic volume (r = 0.6, p &lt; 0.001), and LA ejection fraction (AEF) (r=\u20100.33, p = 0.05). The AEF was preserved when LAD increased in the patients without PAF (0.52 \u00b1 0.07 vs. 0.57 \u00b1 0.10, p = NS), however was significantly decreased in the PAF group (0.37 \u00b10.12 vs. 0.49 \u00b1 0.10, p = 0.01). On multivariate logistic regression analysis, only \u03b4P retained significance on development of PAF.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: It was concluded that \u03b4P increased in patients with PAF and normal LA size. In controls with increased LA size, \u03b4P increased but did not reach the levels attained in patients with PAF. The AEF was decreased in patients with PAF but was preserved in those without PAF. These findings can be explained by the changes in LA microarchitecture which concurrently decreased atrial myocardial contraction, increased \u03b4P, and predisposed to PAF.<\/jats:p>","DOI":"10.1002\/clc.4960241008","type":"journal-article","created":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T23:36:17Z","timestamp":1233704177000},"page":"676-680","source":"Crossref","is-referenced-by-count":40,"title":["Effect of left atrial size and function on P\u2010wave dispersion: A study in patients with paroxysmal atrial fibrillation"],"prefix":"10.1002","volume":"24","author":[{"given":"Tufan","family":"T\u00fcukek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vakur","family":"Akkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dursun","family":"Atilgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015esleref","family":"Demirel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"\u00d6ZCAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zen","family":"G\u00fcuven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferruh","family":"Korkut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1994.00420130036007"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00642-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.58.3.356"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.48.1.39"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(98)70030-4"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.1281"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)80028-F"},{"key":"e_1_2_1_9_2","unstructured":"Declaration of Helsinki:Recommendation guiding physicians in biomedical research involving human subjects. 41 st World Medical Assembly Hong\u2010Kong September1989"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.29.2.242"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.54.4.553"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.62.2.212"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.6.1072"},{"issue":"10","key":"e_1_2_1_14_2","first-page":"1029","article-title":"Pharmacological cardioversion of isolated atrial fibrillation: Recovery of atrial mechanical function and correlation with duration of arrhythmia","volume":"27","author":"Bellandi F","year":"1997","journal-title":"G Itd Cardiol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.3.384"},{"issue":"4","key":"e_1_2_1_16_2","first-page":"261","article-title":"Effect of left atrial size on recurrence of atrial fibrillation after electrical cardioversion: Atrial dimension versus volume","volume":"10","author":"Volgman AS","year":"1996","journal-title":"Am J Card Imaging"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90558-4"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009759717250"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960241008","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960241008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T16:15:52Z","timestamp":1700410552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960241008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["10.1002\/clc.4960241008"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960241008","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10]]}}}