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Cardiac manifestations mostly included myocardial infarctions. Smoking and hyperlipidemia were the most common risk factors for CHD, reported in 72 and 81% of the patients, respectively. Hypercholesterolemia was observed in 75% of the cases at the time of the cardiovascular event. Ninety percent of the patients with pretreatment normal lipid values experienced a rise in the plasma lipid levels during PI therapy. Although a definite relationship between the development of CHD and HIV Pis can not be made, this analysis suggests that Pi\u2010induced hyperlipidemia may play a role in accelerating coronary atherosclerosis in patients with concomitant risk factors. Evaluation and control of risk factors for CHD should be performed in each patient for whom treatment with a PI is indicated.<\/jats:p>","DOI":"10.1002\/clc.4960241011","type":"journal-article","created":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T23:34:50Z","timestamp":1233704090000},"page":"690-694","source":"Crossref","is-referenced-by-count":21,"title":["Coronary heart disease associated with the use of human immunodeficiency virus (HTV)\u20101 protease inhibitors: Report of four cases and review"],"prefix":"10.1002","volume":"24","author":[{"given":"Michel","family":"Duong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marielle","family":"Buisson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Cottin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Piroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Lhuillier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Grappin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Chavanet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Eric","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Portier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ajhp\/55.3.233","article-title":"Protease inhibitors for the treatment of human immunodeficiency virus infection","volume":"55","author":"Katuda T","year":"1998","journal-title":"Am J Health Syst Pharm"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.19.4.281.30937"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/S0140-6736(98)26026-0","article-title":"Vascular complications associated with the use of HIV protease inhibitors (letter)","volume":"351","author":"Berhens G","year":"1998","journal-title":"Lancet"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199815000-00024"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0140-6736(05)78643-8","article-title":"Vascular complications associated with the use of HIV protease inhibitors (letter)","volume":"351","author":"Gallet B","year":"1998","journal-title":"Lancet"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)79053-X"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","unstructured":"J\u00fctteA Salzberger Franzen C R\u00f6merK ComelyD DietF DiehlV F\u00e4tkenheuerG SalzbergerB: Increased morbidity from myocardial infarction during HIV protease inhibitor treatment (abstr 656). 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