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Enhanced MCP\u20101 expression has been detected in macrophages, endothelial cells, and vascular smooth muscle cells in the atheromatous plaque. Activation of macrophages by MCP\u20101 also appears to be involved in the vulnerability of the plaque. Indeed, circulating MCP\u20101 levels are elevated in patients with acute myocardial infarction and in those with unstable angina, but not in patients with stable angina. Production of MCP\u20101 and macrophage accumulation are also observed after coronary angioplasty or grafting, indicating that MCP\u20101 expression may be related not only to instability of atheromatous plaques, but also to the formation of restenotic lesions. The development of therapeutic drugs for atherosclerosis targeted specially against MCP\u20101 may be useful in the prevention of plaque formation and future myocardial infarction.<\/jats:p>","DOI":"10.1002\/clc.4960250403","type":"journal-article","created":{"date-parts":[[2007,6,27]],"date-time":"2007-06-27T13:48:13Z","timestamp":1182952093000},"page":"143-147","source":"Crossref","is-referenced-by-count":74,"title":["Monocyte chemoattractant protein\u20101 and coronary artery 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