{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:22:16Z","timestamp":1789201336806,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":1556,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: The extracellular matrix tissue of the myocardium importantly contributes to left ventricular (LV) performance. Inherited connective tissue disorders related to the FBN1 gene could involve cardiac interstitium resulting in functional abnormalities.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: To disclose a primary involvement of myocardium, LV function was studied in 28 patients affected by Marfan syndrome or Marfan\u2010related disorders: 20 Marfan and 8 MASS (Mitral valve prolapse, Myopia, Aortic dilatation, Skeletal involvement, Skin striae) and in 28 healthy, age and gender\u2010matched controls. No valvular regurgitation or any other cardiac alterations were present.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Echocardiographic study was performed to investigate LV systolic and diastolic function.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: No statistically significant differences were observed between patients and the control group in LV dimensions, systolic function parameters (ejection and shortening fraction), and some diastolic function parameters (E peak, A peak, E\/A), while statistically significant differences were found between patients and the control group in LV mass (128.7 \u00b1 46.6 vs. 83.7 \u00b1 14.5 g\/m<jats:sup>2<\/jats:sup>, p &lt; 0.008), in isovolumic relaxation time (102.0 \u00b1 24.0 vs. 80.1 \u00b1 11.2 ms, p&lt;0.016), and in deceleration time of the E wave (127.5 \u00b1 19.3 vs. 208.6 \u00b1 24.5 ms, p &lt; 0.001) and the A wave (66.4 \u00b1 8.2 vs. 87.5 \u00b1 23.4 ms,p&lt; 0.008).<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: These data show an unusual pattern of transmitral diastolic flow in which a decreased ventricular compliance and reduced myocardial relaxation coexist. Thus, in Marfan syndrome and in Marfan\u2010related disorders, subclinical diastolic alterations are present independent of valvular disease and might represent an early marker of primary myocardial involvement.<\/jats:p>","DOI":"10.1002\/clc.4960250905","type":"journal-article","created":{"date-parts":[[2007,6,27]],"date-time":"2007-06-27T14:51:13Z","timestamp":1182955873000},"page":"416-420","source":"Crossref","is-referenced-by-count":22,"title":["Diastolic subclinical primary alterations in marfan syndrome and marfan\u2010related disorders"],"prefix":"10.1002","volume":"25","author":[{"given":"Maria 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