{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:59:49Z","timestamp":1785376789977,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,7,5]],"date-time":"2007-07-05T00:00:00Z","timestamp":1183593600000},"content-version":"vor","delay-in-days":1707,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Inflammatory process plays an important role in the pathogenesis of acute coronary syndromes.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: The study was undertaken to evaluate whether admission levels of C\u2010reactive protein (CRP), fibrinogen, interleukin\u20106 (IL\u20106), and macrophage colony stimulating factor (MCSF) can predict short\u2010term prognosis in patients with unstable angina.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: C\u2010reactive protein, fibrinogen, IL\u20106, and MCSF were measured on admission in 141 consecutive patients, aged 59 \u00b1 10 years, with unstable angina (Braunwald class IIIb). Patients were divided into two groups according to their in\u2010hospital outcome: Group 1 comprised 77 patients with a complicated course (2 died, 15 developed nonfatal myocardial infarction, and 60 had recurrence of angina), and Group 2 comprised 64 patients with an uneventful course.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Admission median levels of CRP (8.8 vs. 3.1 mg\/l, p = 0.0002), fibrinogen (392 vs. 340 mg\/dl, p = 0.008), IL\u20106 (8.8 vs. 4.5 pg\/ml, p = 0.03), and MCSF (434 vs. 307 pg\/ml, p = 0.0001) were higher in Group 1 than in Group 2. The MCSF levels were an independent risk factor for in\u2010hospital events, with an adjusted odds ratio for eventful in\u2010hospital outcome of 3.3 (95% confidence interval 1\u2010\u201010.9, p = 0.04), and correlated with levels of IL\u20106 (r<jats:sub>s<\/jats:sub> = 0.52, p = 0.0001), CRP (r<jats:sub>s<\/jats:sub> = 0.43, p = 0.0001), and fibrinogen (r<jats:sub>s<\/jats:sub> = 0.25, p = 0.004).<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: These findings suggest that among the studied inflammatory indices only increased admission levels of MCSF are strongly and independently related with adverse short\u2010term prognosis in patients with severe unstable angina.<\/jats:p>","DOI":"10.1002\/clc.4960251106","type":"journal-article","created":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T07:31:07Z","timestamp":1247729467000},"page":"505-510","source":"Crossref","is-referenced-by-count":29,"title":["Prognostic Value of C\u2010Reactive Protein, Fibrinogen, Interleukin\u20106, and Macrophage Colony Stimulating Factor in Severe Unstable Angina"],"prefix":"10.1002","volume":"25","author":[{"given":"Loukianos S.","family":"Rallidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Zolindaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen S.","family":"Manioudaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos G.","family":"Papasteriadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos P.","family":"Laoutaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aggeliki H.","family":"Velissaridou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"F2","article-title":"State of the art: ACS treatment at the turn of the century","volume":"2","author":"Califf RM","year":"2000","journal-title":"Eur Heart J"},{"key":"e_1_2_1_3_2","first-page":"K5","article-title":"Patient stratification and its predictive value for cardiac events","volume":"19","author":"Topol E","year":"1998","journal-title":"Eur Heart J"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408183310701"},{"issue":"10","key":"e_1_2_1_5_2","first-page":"1439","article-title":"Prognostic value of plasma fibrinogen concentration in patients with unstable angina and non\u2010Q\u2010wave myocardial infarction (TIMI IIIB Trial)","volume":"79","author":"Becker RC","year":"1997","journal-title":"Am J Cardiol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.12.4204"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.874"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-199703000-00004"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.16.2079"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00583-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.4.371"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00942-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80710-3"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.8.707"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.8.793"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90350-X"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.775"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(92)90025-L"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-77377-8_5"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(91)90235-U"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/344254a0"},{"issue":"38","key":"e_1_2_1_23_2","first-page":"11","article-title":"A macro and micro view of coronary vascular insult in ischaemic heart disease","volume":"82","author":"Davies MJ","year":"1990","journal-title":"Circulation"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.1.243"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.9.3042"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.15.1758"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-11-199906010-00018"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.1.96"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1656337"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1001\/jama.1987.03400090067035","article-title":"Fibrinogen and risk of cardiovascular disease: The Framingham Study","volume":"258","author":"Kannel WB","year":"1987","journal-title":"J Am Med Assoc"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.1.9"},{"key":"e_1_2_1_32_2","first-page":"588","article-title":"Interleukin 6: A multifactorial cytokine regulating immune reactions and the acute phase protein sequence","volume":"61","author":"Le J","year":"1989","journal-title":"Lab Invest"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.3109\/07357909309046948"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960251106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960251106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T13:15:12Z","timestamp":1700226912000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960251106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1002\/clc.4960251106"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960251106","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}