{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:40:08Z","timestamp":1791898808689,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":1344,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Septal perfusion defects are common on my\u2010ocardial perfusion single\u2010photon emission computed tomography (SPECT) slices in patients with left bundle\u2010branch block (LBBB) in the absence of coronary artery disease.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: The use of gated myocardial perfusion SPECT imaging in such patients should be clinically validated. The aims of this study were, therefore, to validate clinically the use of gated myocardial SPECT imaging to avoid false positive septal perfusion defects in patients with LBBB and to compare nongated and gated SPECT imaging techniques in the same patients in the same imaging session.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: We performed stress\u2010rest myocardial perfusion SPECT and resting gated SPECT using Technetium\u201099m MIBI in 25 patients with LBBB and in 6 control subjects. Stress\u2010rest SPECT images and end\u2010diastolic and end\u2010systolic gated SPECT slices were assessed visually and quantitatively (septum\/lateral wall count ratio). Coronary angiography was performed in 15 patients with LBBB and in all 6 control subjects.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Stress\u2010rest (nongated) SPECT slices and end\u2010diastolic and end\u2010systolic gated SPECT images were normal in all control subjects. Stress\u2010rest (nongated) SPECT imaging revealed septal perfusion defect in 20 (11 reversible, 9 irreversible) patients with LBBB, whereas the figures were 15 and 5 for end\u2010systolic and end\u2010diastolic gated SPECT images, respectively. Coronary angiography results were normal in all control subjects and in 15 patients with LBBB. Quantitative analysis of gated SPECT images revealed no statistically significant difference between patients with LBBB and control subjects in end\u2010diastolic mean septum\/lateral wall count values (0.86 \u00b1 0.19 in LBBB vs. 0.98 \u00b1 0.15 in normal subjects, p &gt; 0.05), but the difference was statistically significant for end\u2010systolic, stress, and rest values (p &lt; 0.001 for all).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Gated SPECT imaging, particularly end\u2010diastolic images, revealed fewer false positive results and thus can be used to avoid false positive septal perfusion defects commonly seen in stress\u2010rest (nongated) myocardial perfusion SPECT in patients with LBBB.<\/jats:p>","DOI":"10.1002\/clc.4960260407","type":"journal-article","created":{"date-parts":[[2007,6,27]],"date-time":"2007-06-27T16:50:35Z","timestamp":1182963035000},"page":"182-187","source":"Crossref","is-referenced-by-count":15,"title":["Clinical validation of technetium\u201099m MIBI\u2010gated single\u2010photon emission computed tomography (SPECT) for avoiding false positive results in patients with left bundle\u2010branch block: Comparison with stress\u2010rest nongated SPECT"],"prefix":"10.1002","volume":"26","author":[{"given":"Hakan","family":"Demir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcner","family":"Erbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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