{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:57:32Z","timestamp":1788587852613,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":1038,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: The Thrombolysis in Myocardial Infarction risk score (TIMI\u2010RS) for unstable angina\/non\u2010ST elevation myocardial infarction (MI) was developed in patients presenting with unstable angina accompanied by high\u2010risk features or non\u2010ST elevation MI to determine early risk stratification.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: The validity in patients presenting for emergency care with symptoms suggestive of acute coronary syndrome (ACS) has not been well established, and the present study sought to do so by evaluating the TIMI\u2010RS in a prospective fashion.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: A prospective TIMI\u2010RS using seven variables was calculated in 245 patients admitted to the hospital with symptoms suggestive of ACS: (1) age &gt; 65, (2) three or more cardiac risk factors, (3) ST deviation, (4) aspirin use within 7 days, (5) two or more anginal events over 24 h, (6) history of coronary stenosis, and (7) elevated troponin. Patients were contacted at 30 days and data were collected concerning major adverse cardiac events.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: In patients presenting with chest pain, a higher TIMI\u2010RS was associated with an increase in major adverse cardiac events within 30 days. We found that the 30\u2010day event rate was 0% for a score of 1, 20% for a score of 2, 24% for a score of 3, 42% for a score of 4, 52% for a score of 5, and 70% for a score of 6 or 7 (p &lt; 0.0001).<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: The TIMI\u2010RS successfully differentiates early risk for major adverse cardiac events in a general population presenting with symptoms suggestive of acute coronary syndrome. A simple bedside calculation of the TIMI\u2010RS provides rapid risk stratification, allowing facilitation of therapeutic decision making in patients with symptoms suggestive of ACS.<\/jats:p>","DOI":"10.1002\/clc.4960270206","type":"journal-article","created":{"date-parts":[[2007,6,27]],"date-time":"2007-06-27T20:46:50Z","timestamp":1182977210000},"page":"74-78","source":"Crossref","is-referenced-by-count":16,"title":["A population\u2010based evaluation of the thrombolysis in myocardial infarction risk score for unstable angina and non\u2010ST elevation myocardial infarction"],"prefix":"10.1002","volume":"27","author":[{"given":"Beth A.","family":"Bartholomew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Sheps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Monroe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"McGorray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","article-title":"Deaths: Final data for 1998","volume":"48","author":"Murphy SL","year":"2000","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(97)70317-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2000.105601"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0196-0644(05)81945-6","article-title":"Missed diagnoses of acute myocardial infarction in the emergency department: Results from a multicenter study","volume":"22","author":"McCarthy BD","year":"1993","journal-title":"Ann Emerg Med"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004203421603"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)10285-X"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00485-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610313351802"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00943-8"},{"key":"e_1_2_1_11_2","first-page":"51","article-title":"The FRISC experience with troponin T. 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