{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T05:17:58Z","timestamp":1719983878084},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":978,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Congestive heart failure is the most common cause of mortality in patients with end\u2010stage renal disease (ESRD). However, noninvasive assessment for cardiac involvement in ESRD has not been established.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: Assessment of ultrasonic tissue characterization and serum markers of collagen degradation is useful for defining myocardial involvement in ESRD.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Cyclic variation of ultrasonic integrated back\u2010scatter of the ventricular septum (CV\u2010IBS) and the serum levels of free matrix metalloproteinase\u2010I (MMP\u2010I) and tissue inhibitor of metalloproteinase\u2010I (TIMP\u2010I) were measured in 30 patients with ESRD undergoing routine hemodialysis (HD) and in 40 patients with essential hypertension (HTN).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Compared with the group with HTN, ESRD (before HD) showed larger left ventricular (LV) mass index (217 \u00b1 56 vs. 146 \u00b1 45 g\/m<jats:sup>2<\/jats:sup>, p &lt; 0.01), worse LV diastolic function (E\/A, 0.6 \u00b1 0.2 vs. 0.9 \u00b1 0.3, p &lt; 0.05), smaller CV\u2010IBS (9.0 \u00b1 1.3 vs. 12.4 \u00b1 0.9 dB, p &lt; 0.01), and larger TIMP\u2010I\/MMP\u2010I (46 \u00b1 10 vs. 34 \u00b1 10, p &lt; 0.05), in spite of the comparable ventricular wall thickness. Thus, these indices may possibly reflect myocardial interstitial fibrosis. After HD (after the improvement of myocardial interstitial edema), a negative linear relationship between CV\u2010IBS and TIMP\u2010I\/MMP\u2010I was observed (r = \u22120.52, p&lt; 0.05).<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: Noninvasive assessment of ultrasonic tissue characterization and serum markers of collagen type I degradation may be a new diagnostic tool for defining myocardial interstitial fibrosis in patients with ESRD and LV hypertrophy.<\/jats:p>","DOI":"10.1002\/clc.4960270412","type":"journal-article","created":{"date-parts":[[2007,6,27]],"date-time":"2007-06-27T20:54:30Z","timestamp":1182977670000},"page":"228-234","source":"Crossref","is-referenced-by-count":8,"title":["Dynamic assessment of myocardial involvement in patients with end\u2010stage renal disease by ultrasonic tissue characterization and serum markers of collagen metabolism"],"prefix":"10.1002","volume":"27","author":[{"given":"Kaniz","family":"Fatema","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Hirono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuto","family":"Masakane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joji","family":"Nitobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuchika","family":"Takeishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.132"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(99)00057-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00161.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90056-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.4.356"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.4.925"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-199601000-00009"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5385-4_4"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/080370599438400"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816070-00018"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.5.1450"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.62.4.757"},{"issue":"1","key":"e_1_2_1_14_2","first-page":"8","article-title":"Biochemical diagnosis of hypertensive myocardial fibrosis","volume":"53","author":"Diez J","year":"2000","journal-title":"Rev Esp Cardiol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1993.1021"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.6.535"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1999.1052"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000024573.17293.23"},{"key":"e_1_2_1_19_2","unstructured":"The sixth report of the Joint National Committee on the Prevention Detection Evaluation and Treatment of High Blood Pressure.NIH publication1997;No.98\u20134080"},{"key":"e_1_2_1_20_2","volume-title":"Hypertension control. 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