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Although the physiologic role of this molecule is still unclear, novel discoveries within the last few years have suggested numerous mechanisms whereby Lp(a) may contribute to atherosclerosis and its complications in human subjects. These effects may differentially occur in vascular tissue and circulating blood compartments. A complex interplay between tissue\u2010specific effects is probably more relevant to the pathogenicity of this molecule than one single effect alone. This review briefly describes the structure of Lp(a) in relation to its biochemical function, summarizing the current literature on various patho\u2010physiologic mechanisms of Lp(a)\u2010induced vascular disease and the role of cell and tissue\u2010specific effects in promoting atherogenesis and thrombosis.<\/jats:p>","DOI":"10.1002\/clc.4960270503","type":"journal-article","created":{"date-parts":[[2007,6,27]],"date-time":"2007-06-27T21:46:52Z","timestamp":1182980812000},"page":"258-264","source":"Crossref","is-referenced-by-count":86,"title":["Lipoprotein(a): New insights into mechanisms of atherogenesis and thrombosis"],"prefix":"10.1002","volume":"27","author":[{"given":"Arjun","family":"Deb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel M.","family":"Caplice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00733-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41683-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1975.tb00338.x"},{"key":"e_1_2_1_5_2","first-page":"1","article-title":"Studies on an extra pre\u2010beta lipoprotein fraction","volume":"531","author":"Dahlen G","year":"1972","journal-title":"Acta Med Scand"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1001\/jama.1993.03510180065035","article-title":"A prospective study of lipoprotein(a) and the risk of myocardial infarction (see comments)","volume":"270","author":"Ridker PM","year":"1993","journal-title":"J Am Med Assoc"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(91)90007-P"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(92)90276-M"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1001\/jama.1996.03540070040028","article-title":"Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger. 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