{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:48:36Z","timestamp":1790610516893,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":948,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: The number of patients awaiting heart transplantation is increasing in proportion to the waiting period for a donor. Studies have shown that coenzyme Q10 (CoQ10) has a beneficial effect on patients with heart failure.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: The purpose of the present double\u2010blind, placebo\u2010controlled, randomized study was to assess the effect of CoQ10 on patients with end\u2010stage heart failure and to determine if CoQ10 can improve the pharmacological bridge to heart transplantation.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: A prospective double\u2010blind design was used. Thirty\u2010two patients with end\u2010stage heart failure awaiting heart transplantation were randomly allocated to receive either 60 mg U\/day of Ultrasome\u2122\u2010\u2010\u2010CoQ10 (special preparation to increase intestinal absorption) or placebo for 3 months. All patients continued their regular medication regimen. Assessments included anamnesis with an extended questionnaire based partially on the Minnesota Living with Heart Failure Questionnaire, 6\u2010min walk test, blood tests for atrial natriuretic factor (ANF) and tumor necrosis factor (TNF), and echocardiography.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Twenty\u2010seven patients completed the study. The study group showed significant improvement in the 6\u2010min walk test and a decrease in dyspnea, New York Heart Association (NYHA) classification, nocturia, and fatigue. No significant changes were noted after 3 months of treatment in echocardiography parameters (dimensions and contractility of cardiac chambers) or ANF and TNF blood levels.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: The administration of CoQ10 to heart transplant candidates led to a significant improvement in functional status, clinical symptoms, and quality of life. However, there were no objective changes in echo measurements or ANF and TNF blood levels. Coenzyme Q10 may serve as an optional addition to the pharmacologic armamentarium of patients with end\u2010stage heart failure. The apparent discrepancy between significant clinical improvement and unchanged cardiac status requires further investigation.<\/jats:p>","DOI":"10.1002\/clc.4960270512","type":"journal-article","created":{"date-parts":[[2007,6,27]],"date-time":"2007-06-27T21:46:52Z","timestamp":1182980812000},"page":"295-299","source":"Crossref","is-referenced-by-count":67,"title":["Coenzyme Q10 in patients with end\u2010stage heart failure awaiting cardiac transplantation: A randomized, placebo\u2010controlled study"],"prefix":"10.1002","volume":"27","author":[{"given":"Marius","family":"Berman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"Erman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuvia","family":"Ben\u2010Gal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Dvir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios P.","family":"Georghiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Stamler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaffa","family":"Vered","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo A.","family":"Vidne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Aravot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"493","volume-title":"Biochemistry","author":"Lehnininger AI","year":"1975"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0670228"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0720092"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01524a047"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(57)90457-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-12-701280-3.50007-4","volume-title":"Function of Quinones in Energy Conserving Systems","author":"King TE","year":"1982"},{"key":"e_1_2_1_8_2","first-page":"380","article-title":"Evidence for a deficiency of coenzyme Q10 in human heart disease","volume":"40","author":"Folkers K","year":"1970","journal-title":"Int J Vitamin Res"},{"key":"e_1_2_1_9_2","first-page":"291","article-title":"Deficiency of coenzyme Q10 in human heart disease, Part 1","volume":"42","author":"Littaru GP","year":"1972","journal-title":"Int J Vitamin Res"},{"key":"e_1_2_1_10_2","first-page":"413","article-title":"Deficiency of coenzyme Q10 in human heart disease, Part 2","volume":"42","author":"Littaru GP","year":"1972","journal-title":"Int J Vitamin Res"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/BF00226851","article-title":"Perspectives on therapy of cardiovascular diseases with coenzyme Q10 (ubiquinone)","volume":"71","author":"Mortensen SA","year":"1993","journal-title":"Clin Invest"},{"key":"e_1_2_1_12_2","first-page":"449","volume-title":"Biomedical and Clinical Aspects of Coenzyme Q","author":"Folkers K","year":"1980"},{"key":"e_1_2_1_13_2","first-page":"168","article-title":"Clinical use of coenzyme Q for treatment of cardiovascular disease","volume":"31","author":"Yamamura Y","year":"1967","journal-title":"Jpn Circ J"},{"key":"e_1_2_1_14_2","first-page":"479","volume-title":"Coenzyme Q Biochemisty, Bioenergetics and Clinical Applications of Ubiquinone","author":"Yamamura Y","year":"1985"},{"key":"e_1_2_1_15_2","first-page":"581","article-title":"Long\u2010term coenzyme Q10 therapy: A major advance in the management of resistant myocardial failure","volume":"8","author":"Mortensen SA","year":"1985","journal-title":"Drug Exp Clin Res"},{"key":"e_1_2_1_16_2","first-page":"577","article-title":"Effective treatment with coenzyme Q10 of patients with chronic myocardial disease","volume":"8","author":"Langsjoen PH","year":"1985","journal-title":"Drug Exp Clin Res"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0098-2997(94)90040-X"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/1071-9164(95)90011-X"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80137-8"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90986-6"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)80289-7"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0098-2997(94)90026-4"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.22.8931"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4240"},{"key":"e_1_2_1_25_2","first-page":"841","article-title":"Effect of coenzyme Q10 on essential arterial hypertension","volume":"47","author":"Digiesi V","year":"1990","journal-title":"Curr Ther Res Clin Exp"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00668-9"},{"issue":"8","key":"e_1_2_1_27_2","first-page":"s134","article-title":"Effect of coenzyme Q10 therapy in patients with congestive heart failure: A long\u2010term multicenter randomized study","volume":"71","author":"Morisco C","year":"1993","journal-title":"Clin Invest"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00064-9"},{"key":"e_1_2_1_29_2","first-page":"23","article-title":"Natriuretic peptides in heart failure","volume":"4","author":"Boland DJ","year":"1998","journal-title":"Cong Heart Fail"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.1.195"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.55"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1997.1070653.x"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(96)02873-2"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.110.4.992"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00159-8"},{"key":"e_1_2_1_36_2","first-page":"3226","article-title":"Interaction between warfarin and coenzyme Q10","volume":"160","author":"Landbo C","year":"1998","journal-title":"Ugeskr Laeger"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960270512","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960270512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:43:16Z","timestamp":1700181796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960270512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1002\/clc.4960270512"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960270512","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}