{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:36:42Z","timestamp":1760297802170},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":917,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background:<\/jats:italic> Dyslipidemia with increased oxidative stress but without elevation of low\u2010density lipoprotein cholesterol has been recently implicated in the pathogenesis of coronary vasospasm.<\/jats:p><jats:p><jats:italic>Hypothesis:<\/jats:italic> Disordered triglyceride\u2010rich lipoprotein metabolism may be linked to the genesis of coronary artery spasm.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> Both serum remnant lipoprotein (RLP) and \u03b1\u2010tocopherol levels were determined in 18 patients with the active stage of variant angina (VA), in 16 patients with the inactive stage of variant angina (IVA), and in 19 control subjects (CONTROL).<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> The RLP levels were significantly (p &lt; 0.05) higher in VA (6.4 \u00b1 2.7 mg\/dl) than in IVA (4.4 \u00b1 1.5 mg\/dl). In contrast, \u03b1\u2010tocopherol levels were significantly lower in VA than that in CONTROL. Serum trigyceride levels were not significantly different among the study groups, although serum high\u2010density lipoprotein cholesterol levels were significantly lower in VA than in CONTROL. Smoking was significantly (p &lt; 0.05) more prevalent in VA (72%) than in IVA (25%) and CONTROL (37%). Serum RLP levels correlated positively with triglyceride levels (R = 0.73) and correlated inversely with \u03b1\u2010tocopherol levels (R = \u2010 0.31) significantly in all study subjects.<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> Patients with active stage of variant angina had higher RLP levels than inactive patients with variant angina and lower \u03b1\u2010tocopherol levels than control subjects. Disordered triglyceride\u2010rich lipoprotein metabolism with increased oxidative stress appears to be linked to the activity of coronary vasospasm, suggesting a possible role in its pathogenesis.<\/jats:p>","DOI":"10.1002\/clc.4960270608","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T04:41:18Z","timestamp":1183005678000},"page":"338-342","source":"Crossref","is-referenced-by-count":11,"title":["High remnant lipoprotein levels in patients with variant 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