{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:50:28Z","timestamp":1792183828783,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":825,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: The finding of aortic regurgitation at a classical examination is a diastolic murmur.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: Aortic regurgitation is more likely to be associated with a systolic than with a diastolic murmur during routine screening by a noncardiologist physician.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: In all, 243 asymptomatic patients (mean age 42 \u00b110 years) with no known cardiac disease but at risk for aortic valve disease due to prior mediastinal irradiation (\u2265 35 Gy) underwent auscultation by a noncardiologist followed by echocardiography. A systolic murmur was considered benign if it was grade \u2264 II\/VI, not holosystolic, was not heard at the apex, did not radiate to the carotids, and was not associated with a diastolic murmur.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Of the patients included, 122 (49%) were male, and 86 (35%) had aortic regurgitation, which was trace in 20 (8%), mild in 52 (21%), and moderate in 14 (6%). A systolic murmur was common in patients with aortic regurgitation, occurring in 12 (86%) with moderate, 26 (50%) with mild, 6 (30%) with trace, and 27 (17%) with no aortic regurgitation (p &lt; 0.0001). The systolic murmurs were classified as benign in 21 (78%) patients with mild and 8 (67%) with moderate aortic regurgitation. Diastolic murmurs were rare, occurring in two (14%) with moderate, two (4%) with mild, and three (2%) with no aortic regurgitation (p = 0.15).<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: An isolated systolic murmur is a common auscultatory finding by a noncardiologist in patients with moderate or milder aortic regurgitation. A systolic murmur in patients at risk for aortic valve disease should prompt a more thorough physical examination for aortic regurgitation.<\/jats:p>","DOI":"10.1002\/clc.4960270905","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T05:16:20Z","timestamp":1183007780000},"page":"502-506","source":"Crossref","is-referenced-by-count":9,"title":["A systolic murmur is a common presentation of aortic regurgitation detected by echocardiography"],"prefix":"10.1002","volume":"27","author":[{"given":"Paul A.","family":"Heidenreich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingela","family":"Schnittger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stsven L.","family":"Hancock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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