{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:42:48Z","timestamp":1773031368748,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":825,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Transcatheter device closure of atrial septal defects (ASD) is an alternative to surgery, but experience is limited in adults, especially in those with large (&gt; 26 mm) defects.<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: We investigated the safety, efficacy, and learning curve for closure of ASD and patent foramen ovale (PFO) using the Amplatzer device.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: In all, 101 procedures were carried out in 100 consecutive adult patients in a single cardiac center between July 1998 and August 2002.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Preprocedure diagnosis was ASD and PFO in 50 patients each. A device was deployed in 94 of 101 attempts (93%) in 94 of 100 patients (94%). Atrial septal defect device sizes were 10\u201038 mm, median 24 mm, and 40% were &gt; 26 mm. Major complications occurred in 2 of 100 patients (2%). One ASD device displaced requiring surgery within 24 h and one patient with PFO experienced pericardial tamponade; there were no deaths. Local vascular complications occurred in 4 of 100 (4%) and late complications in 4 of 100 (4%) patients. Patent foramen ovale closure was quicker (p &lt; 0.001), required less radiation (p=0.04), and was associated with fewer local vascular complications than ASD closure (p = 0.04). Deployment of ASD devices &gt; 26 mm was not associated with increased complications, length of procedure, or radiation compared with devices &lt; 26 mm (all p &gt; 0.05). Complications in the first 35 patients were more frequent than in subsequent patients:7 of 35 (20%) versus 3 of 65 (4.6%) (p = 0.04); procedure and fluoroscopy times (both p &lt; 0.001) and radiation doses (p=0.001) were also higher.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: The Amplatzer device is an effective method for transcatheter closure of interatrial defects in adults, including large ASDs up to 38 mm. Major complications are uncommon. A learning curve of approximately 35 cases was suggested by the decline of complications, procedure times, and radiation exposure.<\/jats:p>","DOI":"10.1002\/clc.4960270907","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T05:16:20Z","timestamp":1183007780000},"page":"509-513","source":"Crossref","is-referenced-by-count":18,"title":["Closure of defects of the atrial septum in adults using the amplatzer device:100 consecutive patients in a single center"],"prefix":"10.1002","volume":"27","author":[{"given":"I. F.","family":"Purcell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Brecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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