{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:45:18Z","timestamp":1773290718276,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":613,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Heme oxygenase (HO) is a rate\u2010limiting enzyme of endogenetic carbon monoxide (CO) that degrades heme into carbon monoxide, bilirubin, and iron. These products have important physiologic effects: bilirubin is a potent antioxidant that can act against ischemia\/reperfusion injury; there is a negative correlation between the content of HO\u20101 and the incidence of coronary heart disease (CHD).<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: This study was undertaken to investigate the changes of HO\u20101 in patients with CHD.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Thirty\u2010five patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP, diagnosed by coronary angiography), and 30 patients with stable angina pectoris (AP, diagnosed by coronary angiography) were selected for the study; another 30 patients with normal coronary artery (diagnosed by coronary angiography) were selected as controls. The levels of HO\u20101 protein expression in monocyte and lymphocyte in the subjects were tested by immunohistochemistry and western blot. Computer picture analyzing systems were also used to measure the levels of HO\u20101 protein expression.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Heme oxygenase\u20101 protein is located in cell plasma. The levels of HO\u20101 protein expression in patients with CHD were significantly higher than in those without CHD (p&lt;0.01). There were significant differences of HO\u20101 expression among the three groups of patients with CHD. The group with AMI was the highest, followed by the group with UAP and finally by the group with AP.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: There is a higher expression of HO\u20101 in patients with CHD. The levels of HO\u20101 protein are associated with the severity of CHD.<\/jats:p>","DOI":"10.1002\/clc.4960280410","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T04:56:37Z","timestamp":1183006597000},"page":"197-201","source":"Crossref","is-referenced-by-count":24,"title":["Study on changes of heme oxygenase\u20101 expression in patients with coronary heart disease"],"prefix":"10.1002","volume":"28","author":[{"given":"S. M.","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. G.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,5]]},"reference":[{"issue":"11","key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1093\/clinchem\/46.11.1723","article-title":"Association of serum bilirubin concentration with risk of coronary artery disease","volume":"46","author":"Mayer M","year":"2000","journal-title":"Clin Chem"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2001.0937"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10274"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3801.095663"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4701.099585"},{"issue":"3","key":"e_1_2_1_7_2","first-page":"711","article-title":"Expression of hemeoxygenase\u20101 in atherosclerotic lesion","volume":"152","author":"Wang LJ","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02054-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0102.101369"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4165"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6163"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/89068"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0741-3_39"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/89068"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.2.H623"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.12.4443"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19980101)68:1<121::AID-JCB12>3.0.CO;2-K"},{"key":"e_1_2_1_18_2","first-page":"433","article-title":"Significance of heme oxygenase in prolactin\u2010mediated cell proliferation and angiogenesis in human endothelial cells","volume":"10","author":"Malaguarnera L","year":"2002","journal-title":"Int J Mol Med"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960280410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960280410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T23:17:10Z","timestamp":1700176630000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960280410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1002\/clc.4960280410"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960280410","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}