{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T19:11:13Z","timestamp":1722885073279},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":522,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: The anti\u2010ischemic benefits of diltiazem are well recognized; however, there are fewer studies of the use of intravenous diltiazem for early treatment of unstable angina pectoris (UAP).<\/jats:p><jats:p><jats:italic>Hypothesis<\/jats:italic>: The present study prospectively evaluated the efficacy, optimal dosage, and safety of continuous intravenous diltiazem for initial management of UAP.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: In all, 102 patients with UAP were recruited in this multicenter trial. Diltiazem was administered as a continuous intravenous infusion with a fixed incremental dosage of 1, 3, and 5 \u03bcg\/kg\/min, titrated according to the patients' symptoms of angina, and then was maintained for a further 48 h at the angina\u2010free dose. Episodes of angina, hemodynamic stability, and complications were observed.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Angina was adequately controlled with continuous intravenous infusion of diltiazem in 64 patients (63%) atados\u2010age of 1 \u03bcg\/kg\/min, in 26 patients (25%) at dosage of 3 \u03bcg\/kg\/min, and in 6 patients (6%) at dosage of 5 \u03bcg\/kg\/min, leading to a cumulative effective ratio of 94% in all patients. Additional anti\u2010ischemic medications were required in six patients (6%) who had refractory angina. Bradyarrhythmias noted in only six patients (6%) were reversible after decreasing the dosage of diltiazem. No acute myocardial infarction or other severe side effects occurred.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Continuous intravenous infusion of diltiazem is well tolerated and relieves symptoms rapidly and effectively in up to 94% patients with UAP, with the majority (63%) treated at the low dosage of 1 \u03bcg\/kg\/min. Diltiazem can be used as a first\u2010line anti\u2010ischemic agent for early conservation treatment of UAP.<\/jats:p>","DOI":"10.1002\/clc.4960280708","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T05:21:27Z","timestamp":1183008087000},"page":"343-348","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of the efficacy, optimal dosage, and safety of diltiazem in early treatment of unstable angina pectoris"],"prefix":"10.1002","volume":"28","author":[{"given":"Rong","family":"Bai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"FOR THE DILTIAZEM CLINICAL TRIAL TASK GROUP OF Wuhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/978-3-642-56225-9_49","volume-title":"Panvascular Medicine: Integrated Clinical Management","author":"Lanzer P","year":"2002"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.10.1193"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.5.1326"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92837-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90222-7"},{"key":"e_1_2_1_7_2","first-page":"773","article-title":"Intravenous diltiazem versus isosorbide dinitrate for unstable angina: Comparison of coronary angiographic morphology in the unstable and stabilized states","volume":"5","author":"Uchida T","year":"1994","journal-title":"Coron Artery Dis"},{"key":"e_1_2_1_8_2","first-page":"409","article-title":"Guidelines for the diagnosis and management of patients with unstable angina","volume":"28","author":"Chinese Cardiology Association\/Editorial Board of Chinese Journal of Cardiology:","year":"2000","journal-title":"Chin J Cardiol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.0874"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199106189-00002"},{"key":"e_1_2_1_11_2","first-page":"931","volume-title":"Cardiovascular Drug Therapy","author":"Pool PE","year":"1996"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960280708","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960280708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T23:21:31Z","timestamp":1700176891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960280708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1002\/clc.4960280708"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960280708","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"type":"print","value":"0160-9289"},{"type":"electronic","value":"1932-8737"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}