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Evidence\u2010based cardiovascular protective therapies, including angiotensin\u2010converting enzyme inhibitors, betablockers, antiplatelet agents, and lipid\u2010lowering medications, improve outcomes for these patients. However, this population is significantly undertreated with these guideline\u2010recommended agents. Critical pathways have been demonstrated to improve the quality and consistency of treatment; as such, the new American College of Cardiology\/American Heart Association (ACC\/AHA) guidelines for the management of patients with ST\u2010elevation myocardial infarction (STEMI) recommend that critical pathways be implemented for the management of these patients. The recent Eplerenone Post\u2010acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) demonstrates that eplerenone, a selective aldosterone blocker, has incremental benefit in decreasing mortality and morbidity when used with standard care therapies in patients post AMI with heart failure and LVSD. The clinical trial evidence coupled with the national guidelines provides a strong rationale for routine incorporation of aldosterone blockade into new or already established critical pathways for AMI complicated by LVSD and heart failure.<\/jats:p>","DOI":"10.1002\/clc.4960290103","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T04:57:39Z","timestamp":1183006659000},"page":"4-8","source":"Crossref","is-referenced-by-count":4,"title":["Hospital protocols and evidence\u2010based therapies: The importance of integrating aldosterone blockade into the management of patients with post\u2014acute myocardial infarction heart failure"],"prefix":"10.1002","volume":"29","author":[{"given":"Gregg 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