{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:21:05Z","timestamp":1790734865772,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We retrospectively analyzed the usefulness and safety of intracoronary acetylcholine (ACh) 200\u2009\u03bcg into the left coronary artery (LCA) as vasoreactivity testing compared with intracoronary ACh 100\u2009\u03bcg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 1433 patients who had angina\u2010like chest pain and intracoronary ACh testing in the LCA, including 1234 patients with a maximum ACh 100\u2009\u03bcg and 199 patients with a maximum ACh 200\u2009\u03bcg. ACh was injected in incremental doses of 20\/50\/100\/200\u2009\u03bcg into the LCA. Positive spasm was defined as \u2265\u200990% stenosis, usual chest pain, and ischemic electrocardiogram (ECG) changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of coronary constriction \u2265\u200990%, usual chest pain, and ischemic ECG changes with a maximum ACh of 100\u2009\u03bcg was markedly higher than that with a maximum ACh of 200\u2009\u03bcg. The frequency of unusual chest pain in patients with a maximum ACh of 200\u2009\u03bcg was higher than that in those with a maximum ACh of 100\u2009\u03bcg (13% vs. 3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In patients with rest angina, positive spasm of maximum ACh 100\u2009\u03bcg was significantly higher than that of maximum ACh 200\u2009\u03bcg, whereas there was no difference regarding positive spasm in patients with atypical chest pain between the two ACh doses. Major complications (1.38% vs. 1.51%, <jats:italic>p<\/jats:italic>\u2009=\u20090.8565) and the occurrence of paroxysmal atrial fibrillation (1.81% vs. 2.63%, <jats:italic>p<\/jats:italic>\u2009=\u20090.6307) during ACh testing in the LCA were not different between the two maximum ACH doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intracoronary ACh 200\u2009\u03bcg into the LCA is clinically useful and safe for vasoreactivity testing when intracoronary ACh 100\u2009\u03bcg dose not provoke spasms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70001","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T08:35:08Z","timestamp":1727858108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety and Usefulness of Intracoronary Acetylcholine 200\u2009\u03bcg Into the Left Coronary Artery as Vasoreactivity Testing: Comparisons With Intracoronary Acetylcholine Maximum 100\u2009\u03bcg"],"prefix":"10.1002","volume":"47","author":[{"given":"Shozo","family":"Sueda","sequence":"first","affiliation":[{"name":"Department of Cardiology Minami Matsuyama Hospital Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Minami Matsuyama Hospital Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ehime Prefectural Niihama Hospital Niihama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Sakaue","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ehime University Graduate School of Medicine Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ehime University Graduate School of Medicine Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.5.955"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90449-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.050"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000046488.52939.BF"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-014-0563-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-66-0098"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00057-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-020-01616-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00126-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004096"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs199"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.016"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.03.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.03.385"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T03:04:17Z","timestamp":1729739057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.70001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/clc.70001"],"URL":"https:\/\/doi.org\/10.1002\/clc.70001","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70001"}}