{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:11Z","timestamp":1753868651694,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vasoreactivity testing, such as intracoronary acetylcholine (ACh) or ergometrine (EM), is defined as Class I\u00a0for the diagnosis of patients with vasospastic angina (VSA) according to recommendations from the Coronary Vasomotion Disorders International Study (COVADIS) group and guidelines from the Japanese Circulation Society (JCS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Although vasoreactivity testing is a clinically useful tool, it carries some risks and limitations\u00a0in\u00a0diagnosing coronary artery spasm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Previous reports on vasoreactivity testing for diagnosing the presence of coronary spasm\u00a0are summarized from the perspective of Class I.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There are several problems\u00a0such as reproducibility, underestimation, overestimation, and inconclusive\/nonspecific\u00a0results associated with daily spasm. Because provoked spasm caused by intracoronary ACh is not always similar to that caused by intracoronary EM, possibly due to different mediators, supplementary use of these vasoreactivity tests is necessary for cardiologists to diagnose VSA\u00a0when a provoked spasm is not revealed by each vasoactive agent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cardiologists should understand the imperfection of these vasoreactivity tests when diagnosing patients with VSA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70004","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T07:44:25Z","timestamp":1724831065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lack of Class I Vasoreactivity Testing for Diagnosing Patients With Coronary Artery Spasm"],"prefix":"10.1002","volume":"47","author":[{"given":"Shozo","family":"Sueda","sequence":"first","affiliation":[{"name":"Department of Cardiology Minami Matsuyama Hospital  Matsuyma City Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Minami Matsuyama Hospital  Matsuyma City Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ehime Prefectural Niihama Hospital  Niihama Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Okabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ehime Prefectural Niihama Hospital  Niihama Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Sakaue","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ehime University Graduate School of Medicine  Touon\u2010shi Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuntaro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ehime University Graduate School of Medicine  Touon\u2010shi Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(59)90003-8"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(78)90810-X"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90080-6"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.3.577"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.5.955"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-74-0802"},{"key":"e_1_2_17_8_1","first-page":"2565","article-title":"International Standardization of Diagnostic Criteria for Vasospastic Angina","volume":"38","author":"Beltrame J. 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