{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:15:32Z","timestamp":1777652132945,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lipoprotein(a) [Lp(a)] plasma level is a well\u2010known risk factor for coronary artery disease (CAD). Existing data regarding the influence of sex on the Lp(a)\u2010CAD relationship are inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between Lp(a) and CAD in men and women and to elucidate any sex\u2010specific differences that may exist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of patients with Lp(a) measurements who were admitted to a tertiary university hospital, Koc University Hospital, were analyzed. The relationship between Lp(a) levels and CAD was explored in all patients and in subgroups created by sex. Two commonly accepted Lp(a) thresholds \u2265\u200930 and \u2265\u200950\u2009mg\/dL were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1858 patients (mean age 54\u2009\u00b1\u200917 years; 53.33% females) were included in the analysis. Lp(a) was an independent predictor of CAD according to the multivariate regression model for the entire cohort. In all cohort, both cut\u2010off values (\u2265\u200930 and \u2265\u200950\u2009mg\/dL) were detected as independent predictors of CAD (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In sex\u2010specific analysis, an Lp(a)\u2009\u2265\u200930\u2009mg\/dL was an independent predictor of CAD only in women (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but Lp(a)\u2009\u2265\u200950\u2009mg\/dL was a CAD predictor both in men and women (men, <jats:italic>p<\/jats:italic>\u2009=\u20090.004; women, <jats:italic>p<\/jats:italic>\u2009=\u20090.047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of this study may suggest that different thresholds of Lp(a) level can be employed for risk stratification in women compared to men.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70012","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T13:01:24Z","timestamp":1726146084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Is There a Need for Sex\u2010Tailored Lipoprotein(a) Cut\u2010Off Values for Coronary Artery Disease Risk Stratification?"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-4718","authenticated-orcid":false,"given":"Ece","family":"Yurtseven","sequence":"first","affiliation":[{"name":"Department of Cardiology Koc University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-1433","authenticated-orcid":false,"given":"Dilek","family":"Ural","sequence":"additional","affiliation":[{"name":"Department of Cardiology Koc University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9661-7878","authenticated-orcid":false,"given":"Erol","family":"Gursoy","sequence":"additional","affiliation":[{"name":"Department of Cardiology Koc University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bekay Omer","family":"Cunedioglu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Koc University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orhan Ulas","family":"Guler","sequence":"additional","affiliation":[{"name":"Department of Cardiology Koc University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8969-590X","authenticated-orcid":false,"given":"Kemal","family":"Baysal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Koc University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1968-0889","authenticated-orcid":false,"given":"Saide","family":"Aytekin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Koc University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2761-7572","authenticated-orcid":false,"given":"Vedat","family":"Aytekin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Koc University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3692-5227","authenticated-orcid":false,"given":"Meral","family":"Kayikcioglu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ege University School of Medicine  Izmir 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