{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:37:40Z","timestamp":1782139060756,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This prospective, randomized trial aimed to compare the efficacy and safety of different intravenous diuretic regimens in acute decompensated heart failure (ADHF) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ADHF patients were enrolled and randomized into three groups: continuous intravenous furosemide infusion (cIV), bolus furosemide injection (bI), and furosemide plus hypertonic saline solution (HSS). Clinical outcomes were assessed over 48\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a study involving 1276 patients admitted for ADHF, three therapeutic regimens (T\u2009\u00d7\u20091, T\u2009\u00d7\u20092, and T\u2009\u00d7\u20093) were compared. T\u2009\u00d7\u20091 administered an 80\u2009mg furosemide intravenous bolus infusion twice daily to 479 patients, while T\u2009\u00d7\u20092 involved a continuous 16\u2010h infusion of 160\u2009mg furosemide daily to 420 patients. T\u2009\u00d7\u20093 treated 377 patients with 160\u2009mg furosemide combined with 150\u2009mL of HSS containing 1.95% NaCl over 30\u2009min. Yet, overall changes in renal markers such as BUN, Na, K, and serum creatinine did not differ significantly. Analysis of prespecified study endpoints revealed notable variations in hospitalization length among the treatment arms. T\u2009\u00d7\u20091 demonstrated a significantly shorter hospital stay (3.7 days) compared to T\u2009\u00d7\u20092 (6.6 days) and T\u2009\u00d7\u20093 (7.9 days). Conversely, alterations in serum creatinine at 48\u2009h, overall changes in serum creatinine, body weight loss, and serum potassium levels did not significantly differ among the treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While intravenous bolus of furosemide showed potential benefits in reducing hospitalization duration, limitations such as a small sample size and short\u2010term observation emphasize the need for larger studies to validate these outcomes further.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70033","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T05:44:16Z","timestamp":1731995056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes of Bolus Dose Furosemide Versus Continuous Infusion in Patients With Acute Decompensated Left Ventricular Failure and Atrial Fibrillation"],"prefix":"10.1002","volume":"47","author":[{"given":"Babar","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Cardiology Lady Reading Hospital Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darab","family":"Shuja","sequence":"additional","affiliation":[{"name":"Department of Medicine Services Hospital Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burhan ul Haq","family":"Saqib","sequence":"additional","affiliation":[{"name":"Department of Cardiology DHQ Hospital Mirpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Liaquat","sequence":"additional","affiliation":[{"name":"Department of Medicine Benazir Bhutto Hospital Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahanzeb","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cardiovascular Analytics Group Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Department of Medicine Military Hospital Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Karim","sequence":"additional","affiliation":[{"name":"Department of Medicine Liaquat University of Medical and Health Sciences Jamshoro Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iftikhar","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Medicine Liaquat University of Medical and Health Sciences Jamshoro Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waheed","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Abbas Institute of Medical Sciences Muzaffrabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4968-3909","authenticated-orcid":false,"given":"Amin","family":"Mehmoodi","sequence":"additional","affiliation":[{"name":"Department of Medicine Ibn e Seena Hospital Kabul Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2048872619894255"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.14744\/AnatolJCardiol.2020.17064"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14038"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-018-9727-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2013.03.015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365519709099409"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(83)90344-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00161-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005419"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.01.355"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.059"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-011-9245-3"},{"issue":"3","key":"e_1_2_10_14_1","first-page":"78","article-title":"Renal 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