{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:14:27Z","timestamp":1783455267094,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Volatile substance (thinner) addiction can cause serious cardiac events, such as malignant ventricular arrhythmias, acute coronary syndromes, sudden death syndrome, and dilated cardiomyopathy, as reported in many case studies. We aimed to find echocardiographic and electrocardiographic parameters that could foresee these adverse outcomes in clinical settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 32 healthy young adult patients with at least 1 year of thinner addiction and no cardiac symptoms. We also recruited a control group of 30 healthy individuals without any medical problems. Both groups received standard echocardiography and ECG tests. We analyzed the following echocardiographic parameters: LVEDd (left ventricular end\u2010diastolic diameter), LVESd (left ventricular end\u2010systolic diameter), mitral valve EF slope, E\/A ratio, and aortic and pulmonary valve VTI (velocity time integral). We also measured the corrected (QTc), uncorrected QT intervals, and widest P\u2010wave values in the ECG. We used the SPSS 13 software for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The echocardiographic findings did not differ significantly between the groups. However, the ECG results showed that the thinner addicts had higher values of corrected (QTc), uncorrected QT intervals, and widest P\u2010wave values than the control group, according to Mann\u2013Whitney <jats:italic>U<\/jats:italic> and Student's <jats:italic>T<\/jats:italic> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Corrected QT (QTc) and P\u2010wave duration are increased in individuals with a thinner addiction. These findings may suggest a higher risk of sudden cardiac death, atrial, and ventricular dysrhythmias in the future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70037","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T11:41:23Z","timestamp":1729770083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Toluene Inhalant Addiction and Cardiac Functions in Young Adults: A Comparison of Electrocardiographic and Echocardiographic Parameters"],"prefix":"10.1002","volume":"47","author":[{"given":"G\u00fcrkan","family":"Karaca","sequence":"first","affiliation":[{"name":"Department of Cardiology Bah\u00e7e\u015fehir University Faculty of Medicine Istanbul Turkey"},{"name":"Department of Cardiology VM Medical Park Maltepe Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdin\u00e7","family":"Hatipsoylu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Educational Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Ekmekci","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bah\u00e7e\u015fehir University Faculty of Medicine Istanbul Turkey"},{"name":"Department of Cardiology Medical Park Pendik Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer Kamil","family":"Yaz\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Ordu University Training and Research Hospital Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0845-9556","authenticated-orcid":false,"given":"Ali","family":"Kimiaei","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bah\u00e7e\u015fehir University Faculty of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedehtina","family":"Safaei","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bah\u00e7e\u015fehir University Faculty of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Bilge","family":"S\u00f6zen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Istanbul University, Faculty of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0470"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.42399"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199005050-00005"},{"key":"e_1_2_8_5_1","first-page":"453","volume-title":"Toksikoloji","author":"Vural N.","year":"1996"},{"issue":"4","key":"e_1_2_8_6_1","first-page":"516","article-title":"U\u00e7ucu Madde Ba\u011f\u0131ml\u0131l\u0131\u011f\u0131 ve T\u0131bbi Sonu\u00e7lar\u0131","volume":"2","author":"Bozta\u015f M. 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