{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:12Z","timestamp":1786977372595,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Coronary artery disease (CAD) and peripheral artery disease (PAD) increase the risks of cardiovascular events and death. Digital health technologies are rapidly expanding to improve healthcare quality and access. The Care4Today Connect (C4T CAD\u2010PAD) mobile application is designed to help patients with CAD and\/or PAD improve medication adherence, learn about their disease, make lifestyle modifications, and enhance healthcare provider (HCP) connection via an HCP\u2010facing portal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis &amp; Methods<\/jats:title>\n                    <jats:p>\n                      The prospective, single\u2010arm, multicenter, noninterventional iPACE\u2010CVD (innovative Patient compAnion impaCting health outcomEs: a CardioVascular Digital health program) study (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT06052319) is evaluating engagement and usefulness of the application for patients with CAD and\/or PAD in clinical settings. Application access is provided with a code from patients' HCPs. Key features include medication and health experience tracking. The application is available in English and Spanish and for iOS and Android devices. Engagement is defined as the proportion of patients who use the application for \u2265\u200910 weeks during the 3\u2010month study period. Application use is defined as the number of patients using \u2265\u20091 application feature(s) each week. Usefulness is determined by the percentage of engaged patients who complete the My Feedback Matters survey with a satisfaction response score of &gt;\u20092 (on a 5\u2010point scale, where 1\u2009=\u2009\n                      <jats:italic>strongly disagree<\/jats:italic>\n                      and 5\u2009=\u2009\n                      <jats:italic>strongly agree<\/jats:italic>\n                      ) for at least three of the six questions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 271 participants were enrolled between November 29, 2023, and May 15, 2024. The study concluded on August 15, 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study will help enhance the application for subsequent studies.\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      NCT06052319\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.70039","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T02:09:18Z","timestamp":1733969358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rationale and Design of a Study to Assess the Engagement and Usefulness of the Care4Today Connect Digital Health Application for Disease Management in Coronary Artery Disease and Peripheral Artery Disease (iPACE\u2010CVD Study)"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1492-2693","authenticated-orcid":false,"given":"Dhanunjaya","family":"Lakkireddy","sequence":"first","affiliation":[{"name":"Kansas City Heart Rhythm Institute HCA Midwest Health Overland Park Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick J.","family":"Angiolillo","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Florida College of Medicine Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristofer","family":"Charlton\u2010Ouw","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences University of Houston College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Jefferson","sequence":"additional","affiliation":[{"name":"Tristar Centennial Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Peeran","sequence":"additional","affiliation":[{"name":"Coastal Cardiothoracic and Vascular Surgery Portsmouth Regional Hospital Portsmouth New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohannad","family":"Bisharat","sequence":"additional","affiliation":[{"name":"Ashchi Heart and Vascular Center and HCA Florida Memorial Hospital Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ortega\u2010Paz","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Florida College of Medicine Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ante","family":"Harxhi","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs, LLC, a Johnson &amp; Johnson Company Titusville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simrati","family":"Kaul","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs, LLC, a Johnson &amp; Johnson Company Titusville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Michaud","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs, LLC, a Johnson &amp; Johnson Company Titusville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Juan","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs, LLC, a Johnson &amp; Johnson Company Titusville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breeana","family":"Woods","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson Technology Solutions Raritan New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CV","family":"Damaraju","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs, LLC, a Johnson &amp; Johnson Company Titusville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Fontana","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute of Los Robles Health System HCA Healthcare Research Institute Thousand Oaks California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-3584","authenticated-orcid":false,"given":"Marc P.","family":"Bonaca","sequence":"additional","affiliation":[{"name":"CPC Clinical Research, Department of Medicine University of Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8295054"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001209"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319707302494"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.5239"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001251"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001168"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2022.05.003"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318535"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012177"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023396"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.06.089"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007425"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000936"},{"key":"e_1_2_12_15_1","unstructured":"\u201cPAD National Action Plan \u201d American Heart Association accessed April 30 2024 https:\/\/professional.heart.org\/-\/media\/PHD-Files-2\/Science-News\/p\/PAD-National-Action-Plan."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.119.005509"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.31478\/202206e"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvdhj.2020.11.001"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12553-022-00651-0"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-41"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j..2002.384.doc.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-1099"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.2.177"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.768986"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.12.011"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-021-10098-9"},{"key":"e_1_2_12_27_1","unstructured":"\u201cMobile Fact Sheet \u201d Pew Research Center accessed August 21 2024 https:\/\/www.pewresearch.org\/internet\/fact-sheet\/mobile\/."},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdgth.2022.880055"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-023-02501-z"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.70039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T02:03:16Z","timestamp":1737684196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.70039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/clc.70039"],"URL":"https:\/\/doi.org\/10.1002\/clc.70039","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70039"}}