{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:19:49Z","timestamp":1788023989497,"version":"build-2784847793"},"reference-count":67,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Psoriasis is a systemic inflammatory disease associated with elevated cardiovascular risk due to inflammatory and oxidative stress. Two\u2010dimensional speckle\u2010tracking echocardiography (2D\u2010STE) can detect both regional and global myocardial strain. Impairment of ventricular strain can assist in the early detection of myocardial dysfunction. Subclinical myocardial dysfunction in psoriasis has not yet been elucidated with inconsistent results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature search of various databases was conducted to identify studies comparing global longitudinal strain (GLS) and global circumferential strain (GCS) between patients with psoriasis and healthy controls. Standardized mean differences (SMD) with 95% confidence intervals (CI) were pooled using the inverse\u2010variance random\u2010effects model in Review Manager Software Version 5.4.1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven studies with 879 participants (501 patients with psoriasis and 378 healthy controls) were included. Psoriasis was associated with a statistically significant reduction in GLS [SMD: \u20131.04; 95% CI: \u20131.45, \u20130.62; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001] and GCS [SMD: \u20130.66; 95% CI: \u20131.27, \u20130.05; <jats:italic>p<\/jats:italic>\u2009=\u20090.03] compared to healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that patients with psoriasis are at an elevated risk of subclinical myocardial dysfunction, as shown by the reduced GLS and GCS. Early assessment of subclinical impairment in psoriasis will allow targeted intervention and may mitigate future adverse cardiovascular events. Prospective studies with larger sample sizes are warranted to validate these results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70047","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T18:31:58Z","timestamp":1733941918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Subclinical Myocardial Dysfunction Assessment Using Speckle Tracking Echocardiography in Patients With Psoriasis: A Pilot Meta\u2010Analysis"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-4299","authenticated-orcid":false,"given":"Hritvik","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Internal Medicine All India Institute of Medical Sciences (AIIMS) Jodhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine All India Institute of Medical Sciences (AIIMS) Jodhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7978-3762","authenticated-orcid":false,"given":"Debankur","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Medical College and Hospital Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishika","family":"Modi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Government Medical College Nagpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Alomari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hamidiye International Faculty of Medicine, University of Health Sciences Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9872-8224","authenticated-orcid":false,"given":"Mushood","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rawalpindi Medical University Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagjot","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Government Medical College Amritsar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramez M.","family":"Odat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine, Jordan University of Science and Technology Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheel","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Heart and Lung Institute, Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-4119","authenticated-orcid":false,"given":"Abdulqadir J.","family":"Nashwan","sequence":"additional","affiliation":[{"name":"Department of Public Health Hamad Medical Corporation Doha Qatar"},{"name":"Department of Public Health College of Health Sciences, QU Health, Qatar University Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3"},{"key":"e_1_2_12_3_1","volume-title":"StatPearls [Internet]. 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