{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:16Z","timestamp":1753868656912,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Concomitant right ventricular (RV) failure and tricuspid regurgitation (TR) are common comorbidities in patients undergoing mitral valve transcatheter edge\u2010to\u2010edge repair (M\u2010TEER) and are associated with worse prognosis. Improvement of TR after M\u2010TEER occurs frequently, however determinants of this course are poorly understood. This study aimed to analyze serum biomarkers that are differentially regulated in patients with TR and to identify biomarkers predictive of the course of TR after M\u2010TEER.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Biomarker expression was analyzed in 242 prospectively included patients undergoing M\u2010TEER. Patients with moderate\u2010to\u2010severe TR had significant comorbidities (median EuroSCORE II 5.2 in patients with severe TR, 4.9 in moderate TR, 3.2 in no\/mild TR; <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and a large number of biomarkers was upregulated including IGFBP\u20102 (1.4\u2010fold in severe TR compared to no\/mild TR, <jats:italic>p<\/jats:italic>\u2009=\u20090.005). Echocardiographic follow\u2010up 3 months after M\u2010TEER was carried out in 99 patients. RV reverse remodeling (RVRR) as defined by improvement of concomitant TR by at least one grade and\/or RV diameter downsizing of at least 10% compared to baseline was seen in 50 patients (50.5%). IGFBP\u20102 (Odds Ratio 2.078) and presence of chronic pulmonary disease (Odds Ratio 15.341) proved independent predictors of non\u2010development of RVRR within 3 months after M\u2010TEER.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients undergoing M\u2010TEER with concomitant moderate or severe TR, numerous cardiometabolic biomarkers including IGFBP\u20102 are upregulated. Higher levels of IGFBP\u20102 at baseline are independently associated with persistent TR and\/or RV dilation after M\u2010TEER.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.70048","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T06:25:52Z","timestamp":1732688752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Insulin\u2010Like Growth Factor Binding Protein 2 Predicts Right Ventricular Reverse Remodeling and Improvement of Concomitant Tricuspid Regurgitation After Transcatheter Edge\u2010to\u2010Edge Mitral Valve Repair"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-3901","authenticated-orcid":false,"given":"Matthias","family":"Gr\u00f6ger","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II Ulm University Heart Center  Ulm Baden\u2010W\u00fcrttemberg 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